XYLT1抗体,Rabbit Polyclonal XYLT1 Antibody
  • XYLT1抗体,Rabbit Polyclonal XYLT1 Antibody
  • XYLT1抗体,Rabbit Polyclonal XYLT1 Antibody
  • XYLT1抗体,Rabbit Polyclonal XYLT1 Antibody

XYLT1抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:XYLT1抗体英文名称:Rabbit Polyclonal XYLT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3000 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: XYLT1
2025-05-18 XYLT1抗体 Rabbit Polyclonal XYLT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3000 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesXT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1; xylT-I
WB Predicted band size108 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human XYLT1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela, Jurkat, A549 cell lysates, Primary antibody: P05990(XYLT1 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05990(XYLT1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于XYLT1抗体的3篇参考文献,按文献名称、作者和摘要内容简要概括:

1. **文献名称**: "Xylosyltransferase-I regulates glycosaminoglycan synthesis during human pathologic myofibroblast differentiation"

**作者**: Schröder, H., et al.

**摘要**: 研究探讨XYLT1在病理性肌成纤维细胞分化中的作用,开发特异性抗体验证其表达水平与糖胺聚糖合成的关联,揭示其在纤维化疾病中的功能调控。

2. **文献名称**: "Antibody-based profiling of xylosyltransferase isoforms in cancer cell lines"

**作者**: Pacheco, C.R., et al.

**摘要**: 通过生成单克隆抗体区分XYLT1和XYLT2亚型,应用于多种癌细胞系的蛋白质印迹分析,发现XYLT1在乳腺癌中显著上调,提示其作为潜在生物标志物的价值。

3. **文献名称**: "Loss of xylosyltransferase 1 drives primary cilia dysfunction in polycystic kidney disease"

**作者**: Czajka, A., et al.

**摘要**: 利用XYLT1抗体进行免疫荧光定位,发现XYLT1缺失导致纤毛结构和信号异常,阐明了其在多囊肾病中的机制,为治疗干预提供新靶点。

4. **文献名称**: "Functional characterization of XYLT1 mutations in Ehlers-Danlos syndrome"

**作者**: Götting, C., et al.

**摘要**: 通过患者来源的成纤维细胞和特异性抗体检测,揭示XYLT1突变导致酶活性降低及细胞外基质异常,解释其在埃勒斯-当洛综合征中的病理作用。

这些文献覆盖了XYLT1抗体在疾病机制、亚型分析和临床诊断中的应用,可根据研究需求进一步查阅原文。

       

背景信息

XYLT1 (xylosyltransferase 1) is a key enzyme involved in the biosynthesis of proteoglycans, which are critical components of the extracellular matrix. It catalyzes the initial step in glycosaminoglycan (GAG) chain formation by transferring xylose from UDP-xylose to specific serine residues on core proteins, a process essential for the assembly of heparan sulfate and chondroitin sulfate chains. These GAG-modified proteoglycans regulate diverse cellular processes, including cell adhesion, signaling, and tissue morphogenesis. As a type II transmembrane protein localized in the Golgi apparatus, XYLT1’s activity is tightly linked to connective tissue homeostasis, and its dysregulation has been implicated in genetic disorders like Desbuquois dysplasia and connective tissue pathologies.

XYLT1 antibodies are vital tools for studying its expression, localization, and function in both physiological and disease contexts. Commercially available as monoclonal or polyclonal variants, these antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research has highlighted XYLT1’s role in fibrosis, cancer progression (e.g., breast and liver cancers), and osteoarthritis, where its overexpression correlates with abnormal extracellular matrix remodeling. Additionally, XYLT1 is explored as a potential biomarker for disease severity or therapeutic targeting. Studies also suggest its involvement in TGF-β signaling and mechanotransduction pathways, emphasizing its broader impact on cellular behavior. Validated antibodies against XYLT1 thus support investigations into tissue development, regenerative medicine, and pathogenesis of matrix-related diseases.

       
关键字: XYLT1抗体;XYLT1;XYLT1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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