**Background of WFDC12 Antibody**
The **WFDC12** (WAP Four-Disulfide Core Domain 12) protein belongs to the WFDC family, characterized by conserved whey acidic protein (WAP) motifs involved in protease inhibition and immune regulation. WFDC12. also known as **HE4** (Human Epididymis Protein 4), is a secreted glycoprotein encoded by the *WFDC2* gene. Initially identified in the epididymis, it is highly expressed in reproductive tissues and certain cancers, particularly ovarian and endometrial carcinomas.
WFDC12 plays roles in modulating innate immunity, inflammation, and extracellular matrix remodeling by inhibiting serine proteases like trypsin and neutrophil elastase. Its overexpression in malignancies has linked it to tumor progression, metastasis, and immunosuppression, making it a biomarker for ovarian cancer diagnosis and monitoring.
Antibodies targeting WFDC12 are critical tools for research and diagnostics. They enable detection of WFDC12 in biological samples (e.g., serum, tissues) via ELISA, immunohistochemistry, or Western blot, aiding in cancer biomarker studies. Therapeutic antibodies are also under exploration to block WFDC12’s pro-tumorigenic functions or enhance immune recognition.
Research on WFDC12 antibodies continues to uncover its pathophysiological roles, offering potential for improved cancer diagnostics, targeted therapies, and insights into protease-mediated disease mechanisms.