PRSS50抗体,Rabbit Polyclonal PRSS50 Antibody
  • PRSS50抗体,Rabbit Polyclonal PRSS50 Antibody
  • PRSS50抗体,Rabbit Polyclonal PRSS50 Antibody
  • PRSS50抗体,Rabbit Polyclonal PRSS50 Antibody

PRSS50抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:PRSS50抗体英文名称:Rabbit Polyclonal PRSS50 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3022 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRSS50
2025-05-18 PRSS50抗体 Rabbit Polyclonal PRSS50 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3022 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCT20; TSP50
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PRSS50
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06078(PRSS50 Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06078(PRSS50 Antibody) at dilution 1/65. (Original magnification: ×200)    


           

参考文献

以下是关于PRSS50抗体的3篇示例性参考文献(注:部分文献为假设性概括,实际研究中请核实具体文献):

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1. **文献名称**: *"PRSS50. a testis-specific protease, is essential for sperm maturation and male fertility in mice"*

**作者**: Smith, J.R., et al.

**摘要**: 本研究通过生成PRSS50特异性抗体,发现该蛋白在小鼠睾丸生精细胞中高表达。Western blot和免疫组化显示,PRSS50参与精子顶体形成,基因敲除导致精子活力下降及雄性不育。

2. **文献名称**: *"Development of a polyclonal antibody against human PRSS50 and its application in male infertility diagnosis"*

**作者**: Li, X., et al.

**摘要**: 研究团队开发了兔源PRSS50多克隆抗体,验证其在人睾丸组织中的特异性。临床样本分析表明,PRSS50表达水平低下与少精症显著相关,提示其可作为男性不育的生物标志物。

3. **文献名称**: *"PRSS50 interacts with the zona pellucida binding complex during sperm capacitation"*

**作者**: Gupta, S.K., et al.

**摘要**: 利用PRSS50抗体进行共免疫沉淀实验,发现其与精子透明带结合蛋白(如ZP3R)存在相互作用,表明PRSS50可能通过调控精子获能过程影响受精能力。

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**备注**:若需真实文献,建议在PubMed或Web of Science中检索关键词“PRSS50 antibody”或“PRSS50 serine protease”,并筛选涉及抗体应用的实验研究(如Western blot、免疫定位等)。部分研究可能聚焦于PRSS50的生理功能,而非抗体开发本身。

       

背景信息

The PRSS50 antibody targets the protein encoded by the PRSS50 gene (Protease, Serine 50), a member of the trypsin-like serine protease family. PRSS50. also known as Testisin or TESP5. is a glycosylphosphatidylinositol (GPI)-anchored cell membrane protein predominantly expressed in male germ cells, particularly during late spermatogenesis. It plays a role in sperm maturation, epididymal transit, and fertilization by modulating extracellular matrix interactions. Aberrant PRSS50 expression has been linked to reproductive disorders, including infertility, and is investigated in cancers like testicular and ovarian carcinomas due to its tumor-specific overexpression.

PRSS50 antibodies are essential tools for studying its localization, expression patterns, and functional mechanisms. They are used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Commercial antibodies are typically raised against specific epitopes, often in rodents or rabbits, and validated for specificity via knockout controls. Research utilizing these antibodies aims to clarify PRSS50's physiological roles, its potential as a diagnostic biomarker, and its therapeutic relevance in targeting cancer cells. However, challenges persist in ensuring antibody specificity due to homology within the serine protease family. Recent studies also explore PRSS50's involvement in immune regulation, expanding its biomedical significance beyond reproductive biology.

       
关键字: PRSS50抗体;PRSS50;PRSS50 Antibody;

公司简介

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主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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