COL25A1抗体,Rabbit Polyclonal COL25A1 Antibody
  • COL25A1抗体,Rabbit Polyclonal COL25A1 Antibody
  • COL25A1抗体,Rabbit Polyclonal COL25A1 Antibody
  • COL25A1抗体,Rabbit Polyclonal COL25A1 Antibody

COL25A1抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:COL25A1抗体英文名称:Rabbit Polyclonal COL25A1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3053 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: COL25A1
2025-05-18 COL25A1抗体 Rabbit Polyclonal COL25A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3053 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAMY; CLAC; CLACP; CFEOM5; CLAC-P
WB Predicted band size65 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human COL25A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A549, Jurkat and A172 cell, Human testis tissue, Hela cell lysates, Primary antibody: P06202(COL25A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06202(COL25A1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇与COL25A1抗体相关的文献概览(均为模拟示例,实际文献需通过数据库验证):

1. **文献名称**: *Collagen XXV interacts with amyloid-β to promote plaque formation in Alzheimer's disease*

**作者**: Yamaguchi H. et al.

**摘要**: 研究发现COL25A1在阿尔茨海默病(AD)患者脑组织中高表达,其抗体标记显示胶原XXV与β-淀粉样蛋白(Aβ)共定位,提示其在淀粉样斑块形成中的潜在作用。

2. **文献名称**: *COL25A1 as a cerebrospinal fluid biomarker for neurodegenerative diseases*

**作者**: Söderberg M. et al.

**摘要**: 通过COL25A1抗体检测脑脊液中的胶原XXV水平,发现其在AD和路易体痴呆患者中显著升高,表明其可能作为神经退行性疾病的生物标志物。

3. **文献名称**: *Characterization of collagen XXV expression in mouse models of muscular dystrophy*

**作者**: Määttä A. et al.

**摘要**: 利用COL25A1抗体分析显示,胶原XXV在肌肉营养不良模型小鼠的神经肌肉接头处特异性富集,提示其参与突触外基质的稳定。

4. **文献名称**: *Immunolocalization of collagen XXV in developing and adult human tissues*

**作者**: Härtig W. et al.

**摘要**: 通过免疫组化结合COL25A1抗体,揭示胶原XXV在胚胎发育期神经管及成人中枢神经系统中的动态表达模式,强调其在组织分化中的潜在功能。

注:以上为模拟生成内容,实际文献需通过PubMed、Web of Science等平台以“COL25A1 antibody”为关键词检索。

       

背景信息

The COL25A1 antibody targets collagen type XXV alpha 1 chain (COL25A1), a transmembrane collagen primarily expressed in the central nervous system (CNS). COL25A1 is a component of the extracellular matrix and is notably associated with amyloid-beta (Aβ) plaques in Alzheimer’s disease (AD). It is synthesized by neurons and accumulates at synaptic sites, where it interacts with Aβ peptides, potentially influencing plaque formation and stability. Research suggests COL25A1 may serve as a scaffold for Aβ deposition, contributing to neurotoxicity and disease progression.

COL25A1 antibodies are critical tools for studying its role in neurodegenerative disorders. They enable the detection of COL25A1 in brain tissues via immunohistochemistry, Western blotting, or ELISA, helping to map its distribution in normal and pathological conditions. Studies using these antibodies have revealed elevated COL25A1 levels in AD brains, correlating with Aβ burden and cognitive decline. Additionally, COL25A1 antibodies aid in investigating its interactions with other plaque-associated proteins and its potential as a therapeutic target.

Despite its niche focus, COL25A1 research highlights the interplay between extracellular matrix components and neurodegenerative mechanisms. Antibodies against COL25A1 remain vital for unraveling its biological functions and exploring diagnostic or therapeutic strategies in AD and related dementias.

       
关键字: COL25A1抗体;COL25A1;COL25A1 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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