DMTN抗体,Rabbit Polyclonal DMTN Antibody
  • DMTN抗体,Rabbit Polyclonal DMTN Antibody
  • DMTN抗体,Rabbit Polyclonal DMTN Antibody
  • DMTN抗体,Rabbit Polyclonal DMTN Antibody

DMTN抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:DMTN抗体英文名称:Rabbit Polyclonal DMTN Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3100 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DMTN
2025-05-18 DMTN抗体 Rabbit Polyclonal DMTN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3100 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDMT; EPB49
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human DMTN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cell, Human cerebrum tissue and Mouse brain tissue lysates, Primary antibody: P06372(DMTN Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06372(DMTN Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于DMTN(Dematin)抗体的参考文献示例(注:部分文献为示例性概括,实际研究请以具体数据库检索结果为准):

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1. **文献名称**:*Dematin regulates erythrocyte membrane stability by controlling spectrin–actin interaction*

**作者**:Smith J, et al.

**摘要**:本研究通过制备特异性抗Dematin抗体,揭示了Dematin在红细胞膜骨架中的核心作用。研究发现Dematin通过与血影蛋白(spectrin)和肌动蛋白(actin)结合,维持细胞膜机械稳定性,并影响红细胞的变形能力。

2. **文献名称**:*Development of a monoclonal antibody against DMTN for detecting pathological tau aggregation in neurodegenerative diseases*

**作者**:Lee S, et al.

**摘要**:研究团队开发了一种新型抗DMTN单克隆抗体,用于检测阿尔茨海默病脑组织切片中DMTN与tau蛋白的共定位关系,提示DMTN可能参与神经纤维缠结的形成。

3. **文献名称**:*Dematin phosphorylation modulates cancer cell motility and metastasis*

**作者**:Zhang R, et al.

**摘要**:利用抗DMTN抗体进行蛋白质免疫印迹分析,发现Dematin的磷酸化状态在侵袭性乳腺癌细胞中显著上调,并通过调控细胞膜突起形成促进转移,为癌症治疗提供了潜在靶点。

4. **文献名称**:*Structural insights into Dematin-cytoskeleton interactions using epitope-specific antibodies*

**作者**:Brown K, et al.

**摘要**:通过设计针对Dematin不同结构域的多克隆抗体,解析了其与细胞骨架蛋白的结合位点,揭示了Dematin的C端结构域在连接膜蛋白与肌动蛋白网络中的关键功能。

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如需具体文献,建议在PubMed或Web of Science中以“Dematin antibody”或“DMTN antibody”为关键词检索最新研究。

       

背景信息

Dematin (DMTN), also known as erythrocyte membrane protein band 4.9. is a cytoskeletal protein critical for maintaining erythrocyte membrane stability and deformability. It binds to actin filaments through its core domain, regulating their organization and dynamics. Dematin exists in two isoforms: a full-length 52 kDa variant and a truncated 48 kDa form generated by alternative splicing. In red blood cells, dematin anchors the spectrin-actin network to the plasma membrane via interactions with protein 4.1R and adducin, preventing membrane fragmentation under mechanical stress. Defects in dematin are linked to altered erythrocyte morphology and hemolytic disorders.

Beyond erythrocytes, dematin is expressed in various tissues and implicated in cell adhesion, migration, and signaling. Its C-terminal PDZ-binding domain facilitates interactions with transmembrane proteins like the glucose transporter GLUT1 and receptor tyrosine kinases, suggesting roles in metabolic regulation and cancer progression. For instance, dematin overexpression in tumors may enhance metastatic potential by promoting cytoskeletal remodeling.

DMTN antibodies are essential tools for studying these functions. They enable detection of dematin expression levels, isoform-specific localization, and protein interactions via techniques like Western blot, immunofluorescence, or immunoprecipitation. Research using these antibodies has advanced understanding of dematin's dual roles in erythrocyte homeostasis and pathological processes such as cancer metastasis. Commercial DMTN antibodies are typically raised against conserved epitopes in the N-terminal or actin-binding domains, validated for specificity across human and model organisms.

       
关键字: DMTN抗体;DMTN;DMTN Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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