EIF3J抗体,Rabbit Polyclonal EIF3J Antibody
  • EIF3J抗体,Rabbit Polyclonal EIF3J Antibody
  • EIF3J抗体,Rabbit Polyclonal EIF3J Antibody
  • EIF3J抗体,Rabbit Polyclonal EIF3J Antibody

EIF3J抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:EIF3J抗体英文名称:Rabbit Polyclonal EIF3J Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3119 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: EIF3J
2025-05-18 EIF3J抗体 Rabbit Polyclonal EIF3J Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3119 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesEIF3S1; eIF3-p35; eIF3-alpha
WB Predicted band size29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenSynthetic peptide of human EIF3J
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Hela, K562, 293T, Jurkat, 231 and SKOV3 cell lysates, Primary antibody: P06421(EIF3J Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06421(EIF3J Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06421(EIF3J Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于EIF3J抗体的3篇参考文献示例(内容为模拟生成,非真实文献):

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1. **文献名称**:*EIF3J regulates translation initiation and promotes tumor progression in breast cancer*

**作者**:Smith A, et al.

**摘要**:研究通过EIF3J抗体进行Western blot和免疫组化分析,发现EIF3J在乳腺癌中高表达,并调控特定mRNA的翻译起始,促进癌细胞增殖和转移。

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2. **文献名称**:*Structural insights into EIF3J's role in the eukaryotic translation initiation complex*

**作者**:Zhang L, et al.

**摘要**:利用EIF3J抗体进行免疫共沉淀(Co-IP)实验,结合冷冻电镜技术解析了EIF3J与真核翻译起始复合物的相互作用,揭示其对核糖体组装的关键结构功能。

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3. **文献名称**:*EIF3J deficiency impairs cellular stress response and apoptosis*

**作者**:Wang Y, et al.

**摘要**:通过敲低EIF3J并结合抗体标记的荧光成像,证明EIF3J缺失会削弱细胞应激颗粒的形成,影响内质网应激通路,导致凋亡信号异常。

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**备注**:以上为示例性内容,实际文献需通过PubMed、Google Scholar等平台检索关键词“EIF3J antibody”或“EIF3J function”获取。建议结合具体研究方向筛选近5年高引用论文。

       

背景信息

The eukaryotic translation initiation factor 3 subunit J (EIF3J), also known as EIF3S1. is a critical component of the eukaryotic initiation factor 3 (eIF3) complex, which plays a central role in protein synthesis. The eIF3 complex, comprising multiple subunits, facilitates the assembly of the 43S pre-initiation complex by promoting ribosomal subunit interactions, scanning mRNA for start codons, and regulating translation initiation under various cellular conditions. EIF3J, specifically, interacts with the 40S ribosomal subunit and other eIF3 components (e.g., EIF3B) to stabilize the complex and ensure proper initiation of protein synthesis. It also participates in mRNA recruitment and ribosome recycling. Beyond its canonical role in translation, EIF3J has been implicated in cell cycle regulation, stress response, and viral infection processes. Dysregulation of EIF3J expression is associated with cancers, neurodegenerative diseases, and other pathologies, highlighting its broader cellular significance. Antibodies targeting EIF3J are essential tools for studying its expression, localization, and interactions in both physiological and disease contexts. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore EIF3J’s functional mechanisms and its potential as a therapeutic or diagnostic marker. Research continues to uncover its context-dependent roles, particularly in cancer progression and translation control pathways.
       
关键字: EIF3J抗体;EIF3J;EIF3J Antibody;

公司简介

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