**Background of ESRP2 Antibody**
The Epithelial Splicing Regulatory Protein 2 (ESRP2) antibody is a tool used to detect ESRP2. an RNA-binding protein critical for regulating alternative splicing events in epithelial cells. ESRP2. along with its homolog ESRP1. modulates the splicing of mRNA precursors to generate protein isoforms that maintain epithelial cell identity. These proteins influence genes involved in cell-cell adhesion, polarity, and motility, such as *FGFR2* and *CD44*, by promoting epithelial-specific splice variants.
ESRP2 expression is predominantly observed in epithelial tissues and is often downregulated during epithelial-mesenchymal transition (EMT), a process linked to cancer metastasis. Loss of ESRP2 correlates with increased tumor invasiveness and poor clinical outcomes, highlighting its role in suppressing EMT and maintaining epithelial integrity.
Antibodies targeting ESRP2 are essential in research to study its expression patterns, splice-regulatory functions, and involvement in diseases like cancer. They are used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess ESRP2 levels in cell lines, tissues, or clinical samples. Such studies help elucidate how ESRP2 dysregulation contributes to pathological states and its potential as a biomarker or therapeutic target. Commercial ESRP2 antibodies are typically validated for specificity and sensitivity to ensure accurate detection across experimental models.