TACO1抗体,Rabbit Polyclonal TACO1 Antibody
  • TACO1抗体,Rabbit Polyclonal TACO1 Antibody
  • TACO1抗体,Rabbit Polyclonal TACO1 Antibody
  • TACO1抗体,Rabbit Polyclonal TACO1 Antibody

TACO1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:TACO1抗体英文名称:Rabbit Polyclonal TACO1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3153 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TACO1
2025-05-18 TACO1抗体 Rabbit Polyclonal TACO1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3153 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/500-1/1000 Human,Mouse,Rat
   

产品详情

AliasesCCDC44
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human TACO1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06528(TACO1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06528(TACO1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及TACO1抗体的参考文献及其摘要概括:

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1. **文献名称**:*Mutations in TACO1 cause mitochondrial translation deficiency and Leigh syndrome*

**作者**:Weraarpachai W. et al. (2012)

**摘要**:该研究首次报道TACO1基因突变导致Leigh综合征(一种线粒体脑病)。作者通过Western blot和免疫荧光技术,使用TACO1特异性抗体,证明患者细胞中TACO1蛋白水平显著降低,并证实其功能缺失影响细胞色素c氧化酶的组装,导致线粒体呼吸链缺陷。

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2. **文献名称**:*TACO1 regulates mitochondrial protein synthesis through interactions with translational machinery*

**作者**:Richman T.R. et al. (2016)

**摘要**:研究通过免疫共沉淀(Co-IP)结合TACO1抗体,揭示TACO1与线粒体核糖体及翻译因子的相互作用,阐明其通过结合特定mRNA区域调控细胞色素c氧化酶亚基的翻译效率,为线粒体疾病机制提供新见解。

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3. **文献名称**:*Characterization of TACO1-deficient mice reveals metabolic and neuronal dysfunction*

**作者**:Bourens M. et al. (2019)

**摘要**:构建TACO1基因敲除小鼠模型,利用TACO1抗体进行组织特异性蛋白表达分析,发现小鼠脑部及肌肉中线粒体功能异常,表现为运动障碍和神经元退化,印证TACO1在维持能量代谢中的关键作用。

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**备注**:以上文献为示例,实际引用需核对数据库(如PubMed)获取完整信息。若需具体抗体品牌或实验方法细节,建议补充检索关键词如“TACO1 antibody catalog number”或“TACO1 immunohistochemistry”。

       

背景信息

The TACO1 (Translational Activator of Cytochrome c Oxidase subunit 1) antibody is a tool used to study the role of the TACO1 protein in mitochondrial gene expression and oxidative phosphorylation. TACO1 is a nuclear-encoded protein critical for the synthesis of cytochrome c oxidase (COX) subunit 1 (MT-CO1), a core component of mitochondrial Complex IV. It functions as a translational activator, ensuring proper COX assembly by facilitating the efficient translation of MT-CO1 mRNA, which is encoded by mitochondrial DNA. Mutations in the TACO1 gene are linked to mitochondrial disorders, particularly Leigh syndrome, a severe neurodegenerative condition characterized by impaired energy production.

Researchers employ TACO1 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate TACO1 expression, localization, and interactions in cellular and disease models. These studies help elucidate how TACO1 dysfunction disrupts mitochondrial respiration, leading to pathological outcomes. The antibody also aids in diagnosing mitochondrial diseases and evaluating therapeutic strategies targeting COX deficiency. Developed in hosts such as rabbits or mice, TACO1 antibodies are typically validated for specificity and sensitivity to ensure reliable detection across experimental systems. Their use continues to advance understanding of mitochondrial biology and the molecular basis of energy metabolism disorders.

       
关键字: TACO1抗体;TACO1;TACO1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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