GUCA1B抗体,Rabbit Polyclonal GUCA1B Antibody
  • GUCA1B抗体,Rabbit Polyclonal GUCA1B Antibody
  • GUCA1B抗体,Rabbit Polyclonal GUCA1B Antibody
  • GUCA1B抗体,Rabbit Polyclonal GUCA1B Antibody

GUCA1B抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:GUCA1B抗体英文名称:Rabbit Polyclonal GUCA1B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3165 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GUCA1B
2025-05-18 GUCA1B抗体 Rabbit Polyclonal GUCA1B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3165 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRP48; GCAP2; GUCA2
WB Predicted band size23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human GUCA1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse eye tissue lysate, Primary antibody: P06557(GUCA1B Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P06557(GUCA1B Antibody) at dilution 1/45. (Original magnification: ×200)    


           

参考文献

以下是关于GUCA1B抗体的3篇参考文献示例(注:文献信息为模拟概括,具体文献需根据实际数据库查询确认):

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1. **文献名称**: "Mutations in GUCA1B Cause Autosomal Dominant Retinal Dystrophy"

**作者**: Newbold RJ, et al.

**摘要**: 本研究通过Western blot和免疫荧光技术,利用GUCA1B特异性抗体,发现其突变导致视网膜中蛋白表达异常,与常染色体显性视网膜营养不良相关,揭示了GUCA1B在光信号转导中的关键作用。

2. **文献名称**: "Calcium Sensitivity of GUCA1B Variants in Retinal Degeneration"

**作者**: Wilke R, et al.

**摘要**: 文章通过免疫共沉淀和ELISA实验,使用GUCA1B抗体分析突变体的钙离子结合能力,表明特定突变削弱了GUCA1B激活鸟苷酸环化酶的功能,导致视网膜病变。

3. **文献名称**: "GUCA1B Antibody Localization in Human Photoreceptors"

**作者**: Dizhoor AM, et al.

**摘要**: 利用GUCA1B抗体的免疫组化技术,研究团队在人类视网膜视锥细胞中定位GUCA1B蛋白,证实其与光感受器特异性鸟苷酸环化酶的共定位,支持其在视觉信号通路中的调控作用。

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**备注**:实际文献需通过PubMed、Google Scholar等平台以关键词“GUCA1B antibody”“GUCA1B retinal dystrophy”等检索获取。若需具体文献,建议提供更详细的研究背景或访问学术数据库。

       

背景信息

The GUCA1B antibody targets the GUCA1B protein, encoded by the GUCA1B gene in humans. This protein, also known as guanylate cyclase activator 1B (GCAP1), belongs to a family of calcium-sensitive proteins that regulate retinal guanylate cyclases (GCs). GCAP1 is predominantly expressed in retinal photoreceptors, where it plays a critical role in phototransduction by modulating the activity of retinal membrane guanylate cyclases (RetGCs). These enzymes catalyze the conversion of GTP to cGMP, a secondary messenger essential for recovering the dark state of photoreceptors after light exposure. Dysregulation of GUCA1B/GCAP1 function has been linked to retinal degenerative diseases, including autosomal dominant cone dystrophy and cone-rod dystrophy, often caused by mutations affecting calcium-binding properties or protein stability.

Antibodies against GUCA1B are widely used in research to study its expression, localization, and interaction with RetGCs in retinal tissues. They are applied in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate molecular mechanisms underlying visual signal transduction and disease pathology. Additionally, these antibodies aid in characterizing disease-associated mutations and evaluating therapeutic interventions. Commercially available GUCA1B antibodies are typically validated for specificity using knockout controls or peptide-blocking assays. Understanding GUCA1B's role in calcium-dependent feedback loops provides insights into retinal physiology and potential targets for treating inherited retinal disorders.

       
关键字: GUCA1B抗体;GUCA1B;GUCA1B Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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