GMEB2 (Glucocorticoid Modulatory Element-Binding Protein 2) is a member of the GMEB family, which plays a regulatory role in glucocorticoid receptor (GR)-mediated gene transcription. Initially identified as a DNA-binding protein interacting with glucocorticoid modulatory elements, GMEB2 forms heterodimers with GMEB1 to enhance or repress GR-dependent transcriptional activity, depending on cellular context. It contains a Kruppel-associated box (KRAB) domain, suggesting potential involvement in chromatin remodeling or protein-protein interactions. Beyond glucocorticoid signaling, GMEB2 is implicated in diverse cellular processes, including viral response pathways, apoptosis regulation, and cell cycle control. Studies link it to adenovirus replication and interferon signaling modulation.
GMEB2 antibodies are essential tools for investigating its expression patterns, subcellular localization, and interactions in both physiological and pathological conditions. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research utilizing these antibodies has revealed GMEB2's widespread tissue distribution and dynamic expression during development or stress responses. Dysregulation of GMEB2 has been observed in certain cancers and autoimmune disorders, highlighting its potential therapeutic relevance. However, its precise mechanistic roles remain partially characterized, necessitating further study. Commercial GMEB2 antibodies are typically raised against specific epitopes within its N-terminal or central regions, with validation recommended for experimental applications.