The GRTP1 (Growth Hormone-Regulated TBC Protein 1) antibody is a tool used to detect and study the GRTP1 protein, a member of the TBC (Tre-2/Bub2/Cdc16) domain-containing family. GRTP1 is implicated in intracellular trafficking and signal transduction processes, particularly through its role as a GTPase-activating protein (GAP) for Rab family GTPases. It is regulated by growth hormone (GH) signaling and has been linked to metabolic pathways, including lipid metabolism and insulin sensitivity. Research suggests GRTP1 may influence vesicle transport, membrane dynamics, and receptor trafficking, with potential relevance to diseases such as cancer, obesity, and diabetes.
The GRTP1 antibody is commonly utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions. Studies have identified GRTP1 expression in various tissues, including liver, adipose tissue, and brain, highlighting its broad physiological roles. Commercial GRTP1 antibodies are typically raised against specific epitopes, often validated for species reactivity (e.g., human, mouse, rat). Recent investigations explore GRTP1's involvement in cancer progression, where altered expression may correlate with tumor growth or metastasis. However, the functional mechanisms of GRTP1 remain under active investigation, necessitating reliable antibodies for ongoing research into its cellular functions and therapeutic potential.