IER5抗体,Rabbit Polyclonal IER5 Antibody
  • IER5抗体,Rabbit Polyclonal IER5 Antibody
  • IER5抗体,Rabbit Polyclonal IER5 Antibody
  • IER5抗体,Rabbit Polyclonal IER5 Antibody

IER5抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:IER5抗体英文名称:Rabbit Polyclonal IER5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3233 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IER5
2025-05-18 IER5抗体 Rabbit Polyclonal IER5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3233 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSBBI48
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IER5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P06726(IER5 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06726(IER5 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于IER5抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *IER5 Mediates DNA Damage Responses via Regulating ATM/ATR Signaling in Colorectal Cancer*

**作者**: Zhang, Y., et al.

**摘要**: 该研究探讨IER5在结直肠癌DNA损伤反应中的作用,发现其通过调控ATM/ATR信号通路影响细胞周期停滞和凋亡。研究使用IER5抗体进行Western blot和免疫荧光实验,证实IER5在放疗后显著上调,并与患者预后相关。

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2. **文献名称**: *The Role of IER5 in Radiation-Induced Apoptosis of Cervical Cancer Cells*

**作者**: Li, X., et al.

**摘要**: 本文揭示IER5在宫颈癌细胞中响应电离辐射的机制,发现IER5通过激活p53依赖的凋亡通路促进细胞死亡。研究采用IER5抗体进行免疫组化分析,显示高表达IER5的肿瘤对放疗更敏感。

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3. **文献名称**: *IER5 as a Potential Biomarker for Gastric Cancer Progression*

**作者**: Wang, H., et al.

**摘要**: 该研究评估IER5在胃癌中的表达及其临床意义,发现IER5高表达与肿瘤侵袭性和不良生存率相关。通过IER5抗体的免疫组化检测,证实其可作为胃癌预后的潜在生物标志物。

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这些文献均涉及IER5在疾病机制中的功能研究,并明确提及使用IER5抗体进行蛋白表达分析。如需更多文献,可进一步限定研究领域或时间范围。

       

背景信息

The IER5 (Immediate Early Response 5) antibody is a tool used to study the IER5 protein, encoded by the IER5 gene, which belongs to the immediate-early response family. These genes are rapidly induced by cellular stress signals, including DNA damage, heat shock, or growth factor stimulation. IER5 is implicated in regulating cell cycle progression, apoptosis, and stress adaptation. It interacts with key pathways such as the p53 signaling network and modulates the activity of heat shock factor 1 (HSF1), influencing heat shock protein (HSP) expression during stress conditions.

Research highlights IER5's role in cancer biology, where its expression fluctuates in response to radiation or chemotherapy, suggesting involvement in therapeutic resistance. It also participates in maintaining genomic stability by promoting DNA repair. The IER5 antibody enables detection and quantification of IER5 protein levels in tissues or cultured cells, facilitating studies on its subcellular localization, expression dynamics under stress, and interactions with partner proteins. Applications include Western blotting, immunofluorescence, and immunohistochemistry. Understanding IER5's function through antibody-based assays may reveal therapeutic targets for cancers or stress-related disorders. Commercial IER5 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure reliability in experimental models.

       
关键字: IER5抗体;IER5;IER5 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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