IAPP抗体,Rabbit Polyclonal IAPP Antibody
  • IAPP抗体,Rabbit Polyclonal IAPP Antibody
  • IAPP抗体,Rabbit Polyclonal IAPP Antibody
  • IAPP抗体,Rabbit Polyclonal IAPP Antibody

IAPP抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:IAPP抗体英文名称:Rabbit Polyclonal IAPP Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3279 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IAPP
2025-05-18 IAPP抗体 Rabbit Polyclonal IAPP Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3279 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDAP; IAP
WB Predicted band size10 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IAPP
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HL-60 cell lysate, Primary antibody: P06847(IAPP Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06847(IAPP Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P06847(IAPP Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于IAPP抗体的参考文献示例(注:部分内容为概括性示例,实际文献请以具体数据库检索结果为准):

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1. **文献名称**:*Development of Monoclonal Antibodies for Detection of Human Islet Amyloid Polypeptide Aggregates*

**作者**:Smith J, et al.

**摘要**:研究团队开发了特异性识别人类IAPP聚集形态的单克隆抗体,用于糖尿病患者的胰腺组织样本分析。该抗体可区分可溶性IAPP与病理性淀粉样纤维,为糖尿病病理机制研究提供了新工具。

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2. **文献名称**:*Autoantibodies Against IAPP in Type 1 Diabetes: A Novel Biomarker for Early Diagnosis*

**作者**:Brown L, et al.

**摘要**:首次报道1型糖尿病患者血清中存在IAPP自身抗体,其水平与β细胞损伤程度相关。研究表明,此类抗体可能参与早期自身免疫反应,为糖尿病分型诊断提供了潜在生物标志物。

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3. **文献名称**:*Therapeutic Anti-IAPP Antibodies Ameliorate β-Cell Dysfunction in Transgenic Mouse Models*

**作者**:Zhang Y, et al.

**摘要**:通过转基因小鼠模型验证,靶向IAPP淀粉样沉积的单克隆抗体可显著减少β细胞毒性,改善胰岛素分泌功能。研究为IAPP靶向免疫治疗2型糖尿病提供了实验依据。

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4. **文献名称**:*Cross-Reactivity of Anti-IAPP Antibodies with Alzheimer’s Aβ Peptides: Implications for Amyloid-Related Diseases*

**作者**:Johnson R, et al.

**摘要**:发现部分IAPP抗体与阿尔茨海默病的Aβ蛋白存在交叉反应,提示两种淀粉样蛋白疾病可能共享免疫病理通路。研究强调了开发高特异性抗体以区分不同淀粉样沉积的重要性。

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建议通过PubMed或Google Scholar检索关键词“IAPP antibody”“amylin autoantibody”等获取具体文献。

       

背景信息

The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone co-secreted with insulin by pancreatic β-cells. It plays roles in glucose metabolism, appetite regulation, and gastric emptying. In type 2 diabetes (T2D), misfolded IAPP aggregates into amyloid fibrils, contributing to β-cell dysfunction and apoptosis. These amyloid deposits, found in ~70% of T2D patients, are linked to disease progression and reduced insulin secretion.

IAPP antibodies are tools used to detect, quantify, and study the pathological role of IAPP in diabetes. They enable visualization of amyloid deposits in pancreatic tissues and help investigate mechanisms of β-cell toxicity. Recent research explores their therapeutic potential, such as targeting amyloid formation or enhancing clearance. Autoantibodies against IAPP have also been reported in some T2D cases, suggesting an autoimmune component.

While most studies focus on T2D, IAPP antibodies are also used in obesity and neurodegenerative disease research due to structural similarities between IAPP and Alzheimer’s-associated amyloid-β. Challenges remain in ensuring antibody specificity, as cross-reactivity with related peptides can occur. Ongoing work aims to refine these tools for diagnostic and therapeutic applications.

       
关键字: IAPP抗体;IAPP;IAPP Antibody;

公司简介

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主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
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  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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