BCOR抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07039(BCOR Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The BCOR (BCL-6 corepressor) antibody targets a protein involved in transcriptional regulation and epigenetic modulation. BCOR functions as a corepressor for BCL-6. a transcriptional repressor critical in lymphocyte differentiation, and interacts with polycomb repressive complex 1 (PRC1) to regulate gene expression during development. It plays roles in cell proliferation, differentiation, and embryogenesis by modifying chromatin structure and repressing target genes.

BCOR mutations or aberrations are linked to cancers such as clear cell sarcoma of the kidney, retinoblastoma-like disorders, and hematologic malignancies (e.g., acute myeloid leukemia). In diagnostics and research, BCOR antibodies are utilized in immunohistochemistry (IHC) and Western blotting to detect BCOR protein expression or loss, aiding in tumor classification and identifying genetic abnormalities. For instance, BCOR immunohistochemistry helps differentiate sarcomas with BCOR alterations from histologic mimics.

The antibody’s relevance extends to studying BCOR’s tumor-suppressive roles and exploring its potential as a biomarker. Abnormal BCOR expression often correlates with disease progression, making it a focus in therapeutic research, particularly for cancers with limited treatment options.