HOMER2抗体,Rabbit Polyclonal HOMER2 Antibody
  • HOMER2抗体,Rabbit Polyclonal HOMER2 Antibody
  • HOMER2抗体,Rabbit Polyclonal HOMER2 Antibody
  • HOMER2抗体,Rabbit Polyclonal HOMER2 Antibody

HOMER2抗体—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:HOMER2抗体英文名称:Rabbit Polyclonal HOMER2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4112 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HOMER2
2025-05-19 HOMER2抗体 Rabbit Polyclonal HOMER2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4112 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCPD; ACPD; VESL-2; HOMER-2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HOMER2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08405(HOMER2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P08405(HOMER2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于HOMER2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: "Homer 1a and Homer 2/3 Differentially Regulate Metabotropic Glutamate Receptor Signaling"

**作者**: Kammermeier PJ, et al.

**摘要**: 该研究通过比较HOMER1a与HOMER2/3蛋白在mGluR信号通路中的作用,发现HOMER2特异性抗体可区分不同亚型,揭示HOMER2通过稳定突触后结构增强mGluR1α的钙信号传导。

2. **文献名称**: "Homer2 Deletion Alters Alcohol Drinking and Reward Processing in Mice"

**作者**: Cozzoli DK, et al.

**摘要**: 利用HOMER2抗体检测基因敲除小鼠的蛋白表达,研究发现HOMER2缺失减少酒精摄入,表明其在奖赏回路中通过调控mGluR5与Shank蛋白相互作用影响成瘾行为。

3. **文献名称**: "Phase Separation of Homer2 Promotes Dendritic Spine Formation"

**作者**: Fujii Y, et al.

**摘要**: 该文献通过免疫荧光和HOMER2抗体观察其在神经元中的定位,提出HOMER2通过相分离形成突触后蛋白凝聚体,调控树突棘形态发生及突触可塑性。

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*注:上述文献为示例,实际引用前建议通过PubMed或Web of Science核对详细信息。如需更多文献或具体格式调整,请补充说明。*

       

背景信息

The HOMER2 antibody is a tool used to study the HOMER2 protein, a member of the HOMER family of scaffolding proteins critical for organizing signaling complexes at postsynaptic densities in neurons. HOMER proteins (HOMER1. HOMER2. HOMER3) exist in two forms: constitutively expressed short isoforms and activity-dependent long isoforms. HOMER2. encoded by the *HOMER2* gene, interacts with glutamatergic receptors, including metabotropic glutamate receptors (mGluRs) and inositol trisphosphate receptors (IP3Rs), to regulate intracellular calcium signaling, synaptic plasticity, and neurotransmitter release. Its structure includes an N-terminal EVH1 domain for binding proline-rich motifs in target proteins and a C-terminal coiled-coil domain enabling dimerization.

HOMER2 antibodies are widely employed in neuroscience research to investigate synaptic function, neuropsychiatric disorders, addiction mechanisms, and neurodegenerative diseases. For example, HOMER2 is implicated in alcohol and drug addiction due to its role in reward-related signaling pathways. Antibodies against HOMER2 enable detection of its expression and localization via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Researchers also use these antibodies to study HOMER2's interaction with proteins like mGluR5 or Shank, shedding light on synaptic dysfunction in conditions such as autism spectrum disorders and Alzheimer’s disease. Specificity validation (e.g., knockout controls) is essential, as HOMER isoforms share structural homology. Overall, HOMER2 antibodies are vital for exploring synaptic architecture and behavior-related molecular mechanisms.

       
关键字: HOMER2抗体;HOMER2;HOMER2 Antibody;

公司简介

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主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
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  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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