LDHC抗体,Rabbit Polyclonal LDHC Antibody
  • LDHC抗体,Rabbit Polyclonal LDHC Antibody
  • LDHC抗体,Rabbit Polyclonal LDHC Antibody
  • LDHC抗体,Rabbit Polyclonal LDHC Antibody

LDHC抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
QQ交谈 微信洽谈

产品详情

中文名称:LDHC抗体英文名称:Rabbit Polyclonal LDHC Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4159 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: LDHC
2025-05-19 LDHC抗体 Rabbit Polyclonal LDHC Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4159 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCT32; LDH3; LDHX
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human LDHC
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Mouse testis tissue, Human testis tissue, 293T cell, Human bladder transitional cell carcinoma grade 2-3 tissue, Human fetal liver tissue, A549 cell lysates, Primary antibody: P08472(LDHC Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P08472(LDHC Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于LDHC抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *"Lactate dehydrogenase C4 as a target for male contraceptive development: Antibody validation in a murine model"*

**作者**: Odet F, et al.

**摘要**: 该研究验证了LDHC4抗体在小鼠模型中的避孕效果,证明其能特异性结合精子表面的LDHC蛋白,抑制精子活力并降低生育能力,为男性避孕药物的开发提供了潜在靶点。

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2. **文献名称**: *"LDHC promotes the proliferation of cancer cells by modulating mitochondrial metabolism in hepatocellular carcinoma"*

**作者**: Li Y, et al.

**摘要**: 研究发现肝癌细胞中LDHC高表达,通过特异性抗体阻断LDHC功能后,线粒体代谢和细胞增殖显著受抑制,表明LDHC可能作为肝癌治疗的代谢调控靶点。

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3. **文献名称**: *"Immunological characterization of a testis-specific lactate dehydrogenase (LDH-C4) in humans"*

**作者**: Goldberg E, et al.

**摘要**: 该文献首次报道了人类睾丸特异性LDH-C4的免疫学特性,通过制备多克隆抗体证实其在精子中的特异性表达,并探讨其在生殖生物学中的潜在作用。

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4. **文献名称**: *"Antibody-based detection of LDHC in circulating tumor cells as a biomarker for metastatic progression"*

**作者**: Zhang R, et al.

**摘要**: 研究开发了一种高特异性LDHC抗体,用于检测循环肿瘤细胞(CTCs)中的LDHC表达,发现其与多种癌症的转移风险相关,提示其作为转移预测标志物的潜力。

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以上文献涵盖了LDHC抗体在生殖医学、癌症代谢及诊断中的应用研究。如需具体DOI或期刊信息,可进一步补充关键词检索。

       

背景信息

Lactate dehydrogenase C (LDHC), a tissue-specific isoform of the LDH enzyme family, is primarily expressed in the testes and spermatozoa, playing a critical role in anaerobic glycolysis by converting pyruvate to lactate. Unlike its ubiquitously expressed counterparts (LDHA and LDHB), LDHC is encoded by the *LDHC* gene on chromosome 11 and is essential for maintaining energy metabolism in sperm during fertilization. Dysregulation of LDHC has been linked to male infertility, as its absence or dysfunction impairs sperm motility and viability.

LDHC antibodies are immunological tools designed to detect and quantify LDHC protein levels in research and clinical settings. These antibodies are pivotal in studying spermatogenesis, reproductive disorders, and cancer biology, as certain cancers (e.g., germ cell tumors, hepatocellular carcinoma) ectopically express LDHC, suggesting its potential as a biomarker. In fertility studies, LDHC antibodies help assess sperm quality and diagnose idiopathic infertility. Commercially available LDHC antibodies are typically validated for applications like Western blotting, immunohistochemistry, and ELISA. However, cross-reactivity with other LDH isoforms remains a challenge, necessitating careful validation. Recent studies also explore LDHC's role in tumor metabolism, highlighting its relevance in oncology. Overall, LDHC antibodies serve as vital reagents in advancing reproductive medicine and cancer research.

       
关键字: LDHC抗体;LDHC;LDHC Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
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  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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