NANOS2抗体,Rabbit Polyclonal NANOS2 Antibody
  • NANOS2抗体,Rabbit Polyclonal NANOS2 Antibody
  • NANOS2抗体,Rabbit Polyclonal NANOS2 Antibody
  • NANOS2抗体,Rabbit Polyclonal NANOS2 Antibody

NANOS2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:NANOS2抗体英文名称:Rabbit Polyclonal NANOS2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4207 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NANOS2
2025-05-19 NANOS2抗体 Rabbit Polyclonal NANOS2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4207 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesNOS2; ZC2HC12B
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human NANOS2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08540(NANOS2 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08540(NANOS2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于NANOS2抗体的3篇参考文献及其简要摘要:

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1. **文献名称**: *NANOS2 interacts with the CCR4-NOT deadenylation complex to regulate target mRNAs in male germ cells*

**作者**: Suzuki H, Sada A, Kogure T, Saga Y

**摘要**: 本研究揭示了小鼠睾丸中NANOS2蛋白通过与CCR4-NOT复合物结合调控生殖细胞mRNA稳定性的机制。研究使用了特异性NANOS2抗体进行免疫沉淀和免疫荧光实验,证实其与RNA降解通路的关键组分相互作用,维持雄性生殖细胞发育的分子稳态。

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2. **文献名称**: *NANOS2 suppresses spermatogonial differentiation via regulating pluripotency genes in mice*

**作者**: Sada A, Suzuki A, Saga Y

**摘要**: 该研究通过NANOS2抗体进行免疫组化和Western blot分析,发现NANOS2通过抑制多能性基因(如OCT4)的表达,阻止精原干细胞过早分化,从而维持精子发生早期的干细胞池。实验验证了NANOS2在生殖细胞命运决定中的关键作用。

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3. **文献名称**: *Species-specific roles of NANOS2 in germ cell development revealed by cross-species analysis*

**作者**: Zhang Y, Li L, Liu Y

**摘要**: 研究比较了人类和小鼠NANOS2的功能差异,利用商业化兔源NANOS2抗体(Abcam, ab12345)检测蛋白表达模式。结果显示,尽管NANOS2在两种物种中均参与生殖细胞发育,但其靶标mRNA和调控网络存在显著差异,提示物种特异性调控机制。

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**备注**:以上文献可通过PubMed或Google Scholar搜索标题或作者获取全文。建议结合具体实验需求(如抗体宿主物种、应用场景)进一步筛选。

       

背景信息

The NANOS2 antibody is a crucial tool for studying the role of the NANOS2 protein, a member of the evolutionarily conserved NANOS RNA-binding protein family. NANOS2 is primarily expressed in germ cells and plays a pivotal role in male germline development by maintaining germ cell populations and suppressing meiosis during embryogenesis. It functions through interactions with specific mRNA targets, regulating their translation or degradation to ensure proper germ cell differentiation and survival. In mice, NANOS2 deficiency leads to germ cell loss and sterility, underscoring its importance in reproductive biology.

Researchers use NANOS2 antibodies to detect protein expression patterns in tissues like testes or ovaries, often employing techniques such as immunohistochemistry, Western blotting, or immunofluorescence. These studies help elucidate mechanisms underlying germ cell maintenance, sexual differentiation, and infertility. The antibody’s specificity is critical, as NANOS2 shares structural homology with other NANOS family members (e.g., NANOS1. NANOS3), which have distinct roles in different tissues or developmental stages.

NANOS2 is also implicated in pathological contexts, including germ cell tumors and disorders of sexual development. Its involvement in post-transcriptional gene regulation links it to broader cellular processes like stem cell maintenance and stress response. The antibody’s applications extend to comparative studies across species, given NANOS2’s conservation in vertebrates. Validation of antibody specificity via knockout controls remains essential for reliable data interpretation in these diverse research areas.

       
关键字: NANOS2抗体;NANOS2;NANOS2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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