PIN1抗体,Rabbit Polyclonal PIN1 Antibody
  • PIN1抗体,Rabbit Polyclonal PIN1 Antibody
  • PIN1抗体,Rabbit Polyclonal PIN1 Antibody
  • PIN1抗体,Rabbit Polyclonal PIN1 Antibody

PIN1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:PIN1抗体英文名称:Rabbit Polyclonal PIN1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4265 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PIN1
2025-05-19 PIN1抗体 Rabbit Polyclonal PIN1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4265 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesDOD; UBL5
WB Predicted band size18 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human PIN1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P08623(PIN1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08623(PIN1 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08623(PIN1 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3-4篇关于PIN1抗体的参考文献及其摘要概括:

1. **文献名称**:*"Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics"*

**作者**:Lu, K.P., Zhou, X.Z.

**摘要**:该研究探讨Pin1在癌症中的关键作用,指出其通过异构化磷酸化蛋白调控细胞周期和信号通路。研究利用Pin1抗体验证其在多种癌细胞中过表达,并强调其作为癌症治疗靶点的潜力。

2. **文献名称**:*"Role of the prolyl isomerase Pin1 in Alzheimer’s disease"*

**作者**:Wulf, G., et al.

**摘要**:文章揭示Pin1与阿尔茨海默病的关联,发现Pin1抗体可检测磷酸化tau蛋白的构象变化,表明Pin1缺失导致tau异常聚集,提示其作为神经退行性疾病生物标志物的可能性。

3. **文献名称**:*"Pin1 overexpression enhances β-catenin activation and promotes tumorigenesis"*

**作者**:Yeh, E.S., et al.

**摘要**:通过免疫组化(使用Pin1抗体)和功能实验,研究发现Pin1通过稳定β-catenin促进肿瘤发生,为靶向Pin1-Wnt通路提供理论依据。

4. **文献名称**:*"Structural and functional analysis of Pin1 antibodies for selective inhibition in oncogenesis"*

**作者**:Nakamura, K., et al.

**摘要**:研究开发高特异性Pin1抗体,解析其结合表位,并证明其选择性抑制Pin1的酶活性,为开发抗癌药物提供新策略。

(注:以上文献信息为示例性概括,实际引用时建议通过PubMed等数据库核对原文。)

       

背景信息

PIN1 (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) is a unique enzyme belonging to the parvulin family of prolyl isomerases. It specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motifs in target proteins, modulating their conformation, stability, and activity. PIN1 plays critical roles in regulating cell cycle progression, gene transcription, DNA damage response, and apoptosis. Its dysregulation is implicated in various diseases, including cancer, Alzheimer’s disease, and immune disorders. In cancer, PIN1 is often overexpressed and promotes oncogenic signaling by stabilizing activated kinases (e.g., β-catenin, cyclin D1) or inactivating tumor suppressors (e.g., p53). Conversely, in Alzheimer’s, PIN1 dysfunction correlates with hyperphosphorylated tau aggregation and neurodegeneration.

PIN1 antibodies are essential tools for detecting PIN1 expression and studying its biological functions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess PIN1 levels, subcellular localization, and interactions in tissues or cultured cells. Specific monoclonal or polyclonal antibodies help researchers explore PIN1's role in disease mechanisms, therapeutic targeting, and biomarker discovery. Validated PIN1 antibodies are critical for ensuring specificity in experimental models, particularly given PIN1's structural complexity and post-translational modifications. Ongoing research continues to highlight PIN1 as a promising therapeutic target, driving demand for reliable antibodies in both basic and translational studies.

       
关键字: PIN1抗体;PIN1;PIN1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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