The SEMA4F antibody targets Semaphorin-4F (SEMA4F), a member of the semaphorin protein family known for its role in axon guidance, cell migration, and immune regulation. SEMA4F is a transmembrane glycoprotein characterized by a conserved "sema" domain, which mediates receptor binding and signaling. It functions as both a ligand and receptor, interacting with plexins and other semaphorin family members to regulate cytoskeletal dynamics and cell-cell communication.
SEMA4F is expressed in diverse tissues, including the nervous and immune systems, and has been implicated in neurodevelopment, angiogenesis, and tumor progression. Studies suggest it modulates neuronal pathfinding during embryogenesis and influences vascular patterning. In cancer, SEMA4F may promote tumor invasiveness by enhancing metastatic pathways or suppressing anti-tumor immunity.
Antibodies against SEMA4F are critical tools for investigating its expression patterns, signaling mechanisms, and pathological roles. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using SEMA4F antibodies has contributed to understanding its dual role in neural repair and cancer metastasis, highlighting its potential as a therapeutic target. Recent studies also explore its involvement in autoimmune disorders, underscoring its broad relevance in biomedical research.