The VPS37A antibody is a crucial tool for studying the vacuolar protein sorting-associated protein 37A (VPS37A), a component of the Endosomal Sorting Complex Required for Transport (ESCRT) system. VPS37A is part of the ESCRT-I complex, which plays a vital role in membrane remodeling processes, including multivesicular body (MVB) formation, cytokinesis, viral budding, and autophagy. The ESCRT machinery ensures proper sorting of ubiquitinated cargo proteins into intraluminal vesicles of MVBs, a process critical for lysosomal degradation or extracellular vesicle release. Dysregulation of VPS37A has been linked to cellular abnormalities, cancer progression, and neurodegenerative disorders.
The VPS37A antibody is primarily used to detect and quantify VPS37A expression in cells or tissues via techniques like Western blotting, immunofluorescence, or immunoprecipitation. Researchers employ it to investigate ESCRT-I function, membrane trafficking dynamics, and disease mechanisms. Polyclonal and monoclonal variants are available, often raised in hosts like rabbits or mice, with validation data ensuring specificity and cross-reactivity across species. Recent studies highlight its utility in exploring VPS37A’s role in exosome biogenesis, receptor downregulation, and cellular stress responses. As ESCRT-related pathways gain attention in cancer and neurodegeneration research, this antibody remains pivotal for dissecting molecular pathways and identifying therapeutic targets.