KCTD16抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human cerebrum tissue, rat brain tissue and Mouse brain tissue, Primary antibody: P09081(KCTD16 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P09081(KCTD16 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The KCTD16 antibody is a specialized tool used to detect the potassium channel tetramerization domain-containing protein 16 (KCTD16), a member of the KCTD family involved in diverse cellular processes. KCTD16 regulates G-protein-coupled receptor (GPCR) signaling, particularly through interactions with GABAB receptors, modulating their trafficking and downstream signaling. It also associates with the Cullin3 ubiquitin ligase complex, influencing protein ubiquitination and degradation. Dysregulation of KCTD16 has been implicated in neurological disorders, cancer, and metabolic diseases, driving interest in its functional characterization.

Antibodies targeting KCTD16 enable researchers to study its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically raised in rabbits or mice, with some validated for specificity using knockout controls. Commercial KCTD16 antibodies often cite applications in brain and peripheral tissue studies, given the protein’s role in neural circuits and cellular homeostasis. Recent studies highlight its potential as a biomarker or therapeutic target, particularly in cancers where KCTD16 expression correlates with disease progression. Researchers prioritize antibodies validated across multiple experimental conditions to ensure reproducibility in both human and murine models.