DAND5抗体,Rabbit Polyclonal DAND5 Antibody
  • DAND5抗体,Rabbit Polyclonal DAND5 Antibody
  • DAND5抗体,Rabbit Polyclonal DAND5 Antibody
  • DAND5抗体,Rabbit Polyclonal DAND5 Antibody

DAND5抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
QQ交谈 微信洽谈

产品详情

中文名称:DAND5抗体英文名称:Rabbit Polyclonal DAND5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4582 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DAND5
2025-05-19 DAND5抗体 Rabbit Polyclonal DAND5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4582 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3
WB Predicted band size20 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue, Primary antibody: P09097(DAND5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P09097(DAND5 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于DAND5抗体的示例参考文献(仅供参考,具体文献需通过学术数据库查询):

---

1. **文献名称**: *DAND5/CER1 regulates TGF-β signaling during left-right patterning via antibody-blocking experiments*

**作者**: Smith J, et al.

**摘要**: 本研究通过开发DAND5特异性多克隆抗体,证明其在斑马鱼胚胎左右轴形成中的作用。抗体阻断实验显示,DAND5通过拮抗Nodal信号调控TGF-β通路,为胚胎发育不对称性提供分子机制。

2. **文献名称**: *Monoclonal antibody generation and functional characterization of DAND5 in colorectal cancer*

**作者**: Zhang L, et al.

**摘要**: 研究团队制备了抗DAND5的单克隆抗体,并用于结直肠癌组织芯片分析。结果显示DAND5在肿瘤间质中高表达,与TGF-β1活性负相关,提示其作为癌症生物标志物的潜力。

3. **文献名称**: *DAND5 antibody-based inhibition suppresses metastatic progression in breast cancer models*

**作者**: Tanaka K, et al.

**摘要**: 利用人源化DAND5抗体靶向治疗乳腺癌小鼠模型,发现抗体通过抑制EMT(上皮间质转化)降低转移率,为靶向DAND5的肿瘤治疗策略提供依据。

4. **文献名称**: *Immunohistochemical localization of DAND5 in stem cell niches using a novel affinity-purified antibody*

**作者**: Lee S, et al.

**摘要**: 本研究优化了DAND5抗体的亲和纯化流程,应用于小鼠肠道干细胞微环境检测,揭示DAND5在维持干细胞静息状态中的空间表达特征。

---

**备注**:以上文献为示例性质,实际研究中请通过 **PubMed** 或 **Web of Science** 检索关键词“DAND5 antibody”“CER1 antibody”等获取最新结果。部分研究可能侧重抗体开发,而另一些侧重应用,建议根据需求筛选。

       

背景信息

The DAND5 antibody targets the DAND5 protein, also known as Cerberus, a secreted glycoprotein belonging to the DAN family of BMP (bone morphogenetic protein) antagonists. DAND5 plays critical roles in embryonic development, particularly in regulating left-right asymmetry by inhibiting Nodal, BMP, and Wnt signaling pathways. It is expressed in dynamic patterns during gastrulation and organogenesis, influencing tissue patterning and cell fate decisions. DAND5 knockout studies in model organisms, such as mice and zebrafish, reveal defects in heart development, neural tube closure, and lateralization, underscoring its importance in establishing body plan symmetry.

Aberrant DAND5 expression has been linked to congenital disorders, including heterotaxy syndromes and congenital heart defects, as well as ciliopathies due to its interaction with ciliary signaling. The DAND5 antibody is widely used in developmental biology research to visualize protein localization, assess expression levels in disease models, and investigate molecular mechanisms underlying left-right axis determination. Its applications extend to stem cell differentiation studies, where DAND5 modulation helps mimic embryonic signaling environments. Structurally, DAND5 contains a conserved cysteine-rich domain essential for ligand binding and inhibition. Recent studies also explore its potential role in cancer, particularly in modulating TGF-β superfamily signaling in tumor microenvironments. The antibody’s specificity and reliability make it a key tool for dissecting early developmental processes and related pathologies.

       
关键字: DAND5抗体;DAND5;DAND5 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

DAND5抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP4年
维百奥(北京)生物科技有限公司
2026-03-02
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
询价
上海华盈生物医药科技有限公司
2026-03-03
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.