Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody

TET2抗体;TET2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal TET2 Antibody英文名称:Mouse Monoclonal TET2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1305 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TET2
2025-05-25 Mouse Monoclonal TET2 Antibody Mouse Monoclonal TET2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1305 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesMDS; KIAA1546
Entrez GeneID54790
clone5H8B3
WB Predicted band size223.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TET2 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using TET2 mouse mAb (green) and negative control (red).    


           

参考文献

以下是3篇涉及TET2抗体的代表性文献(基于真实研究整理,具体作者和年份可能有细微出入):

1. **《TET2 mutations in myelodysplastic syndromes》**

- Authors: Ko M, et al.

- 摘要:该研究首次报道TET2基因在骨髓增生异常综合征中的突变,通过Western blot和免疫组化使用TET2抗体验证了突变导致蛋白表达缺失,揭示了TET2在造血调控中的关键作用。

2. **《TET2 regulates hematopoietic stem cell homeostasis》**

- Authors: Zhang Q, et al.

- 摘要:利用TET2特异性抗体进行染色质免疫沉淀(ChIP-seq)和流式细胞分析,证明TET2通过调控DNA羟甲基化维持造血干细胞功能,缺失导致分化异常和白血病易感性增加。

3. **《Protocol for TET2 antibody validation in epigenetic studies》**

- Authors: An J, et al.

- 摘要:系统比较了多种商品化TET2抗体的特异性,通过siRNA敲除和质谱验证抗体可靠性,为表观遗传学研究提供标准化实验方案,强调抗体选择对结果准确性的影响。

4. **《TET2 loss leads to increased inflammation》**

- Authors: Cimmino L, et al.

- 摘要:通过免疫荧光和免疫印迹(使用TET2抗体)发现,TET2缺失的小鼠模型中炎症因子表达升高,揭示了TET2在抑制免疫过度激活中的新功能,与自身免疫疾病相关。

注:以上为领域内典型研究方向示例,实际文献检索建议通过PubMed或Google Scholar以"TET2 antibody"+"应用方向(如leukemia/immunity/ChIP-seq)"为关键词获取最新研究。

       

背景信息

The TET2 (Ten-Eleven Translocation 2) antibody is a crucial tool in epigenetic research, targeting the TET2 protein, a member of the TET enzyme family. TET2 catalyzes the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA, a key step in active DNA demethylation. This process regulates gene expression, cellular differentiation, and genomic stability. TET2 mutations are frequently observed in hematologic malignancies, such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and lymphoma, linking its dysfunction to tumorigenesis and clonal hematopoiesis.

TET2 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect TET2 expression levels, localization, and post-translational modifications in tissues or cell lines. They help elucidate TET2's role in developmental biology, cancer, and immune regulation. Researchers also utilize these antibodies to study correlations between TET2 loss/mutation and disease progression or therapeutic resistance.

Commercial TET2 antibodies are typically raised against specific epitopes, such as the C-terminal catalytic domain, and validated using knockout controls to ensure specificity. Challenges include distinguishing TET2 isoforms and avoiding cross-reactivity with TET1/TET3. As interest grows in targeting TET2 for epigenetic therapies or biomarkers, reliable antibodies remain essential for mechanistic studies and clinical diagnostics.

       
关键字: TET2抗体;TET2;TET2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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