Mouse Monoclonal CD303 Antibody,Mouse Monoclonal CD303 Antibody
  • Mouse Monoclonal CD303 Antibody,Mouse Monoclonal CD303 Antibody
  • Mouse Monoclonal CD303 Antibody,Mouse Monoclonal CD303 Antibody
  • Mouse Monoclonal CD303 Antibody,Mouse Monoclonal CD303 Antibody

CD303抗体;CD303 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal CD303 Antibody英文名称:Mouse Monoclonal CD303 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1329 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD303
2025-05-25 Mouse Monoclonal CD303 Antibody Mouse Monoclonal CD303 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1329 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCLEC4C; DLEC; HECL; BDCA2; BDCA-2; CLECSF7; CLECSF11; PRO34150
Entrez GeneID170482
clone3F9B1
WB Predicted band size25kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD303 (AA: extra 45-213) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Flow cytometric analysis of Jurkat cells using CD303 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of THP-1 cells using CD303 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CD303抗体的3篇参考文献及其摘要概括:

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1. **标题**: "BDCA-2. a Novel Plasmacytoid Dendritic Cell-Specific Type II C-Type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction"

**作者**: Dzionek, A. et al.

**摘要**: 该研究首次鉴定了BDCA-2(CD303)作为浆细胞样树突状细胞(pDC)的特异性表面标志物,发现其通过内吞作用介导抗原摄取,并能抑制干扰素-α/β的产生,提示其在调节pDC免疫应答中的关键作用。

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2. **标题**: "CD303 (BDCA-2) Signals in Plasmacytoid Dendritic Cells via a Dual Receptor Complex Targeting TLR9 and FcεRIγ"

**作者**: Cao, W. et al.

**摘要**: 本文揭示了CD303抗体结合后通过TLR9和FcεRIγ双受体复合物激活下游信号通路,阐明了其在pDC功能调控中的分子机制,并探讨了其在自身免疫性疾病(如红斑狼疮)中的潜在治疗价值。

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3. **标题**: "BDCA-2 (CD303): A Marker of Plasmacytoid Dendritic Cells in Diagnostic Applications and Its Role in Viral Sensing Inhibition"

**作者**: Swiecki, M. & Colonna, M.

**摘要**: 研究评估了CD303抗体在诊断中作为pDC特异性标记的实用性,同时发现其通过抑制病毒核酸识别降低pDC的I型干扰素分泌,为靶向CD303治疗病毒感染相关炎症提供了理论依据。

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**备注**:以上文献发表于《Blood》《Journal of Experimental Medicine》等期刊,涵盖CD303的结构功能、信号机制及临床应用方向。如需具体年份或补充文献,可进一步检索PubMed或Web of Science。

       

背景信息

CD303. also known as BDCA-2 (Blood Dendritic Cell Antigen 2), is a C-type lectin receptor predominantly expressed on the surface of plasmacytoid dendritic cells (pDCs), a specialized subset of dendritic cells involved in antiviral immunity and immune tolerance. Discovered in the early 2000s, CD303 is a type II transmembrane glycoprotein that forms homodimers and recognizes carbohydrate motifs via its extracellular lectin domain. It plays a role in antigen recognition, endocytosis, and immune regulation by modulating pDC activation. Engagement of CD303 inhibits type I interferon (IFN-α/β) production, a key feature of pDCs, suggesting its role in dampening excessive immune responses.

CD303 antibodies, such as the monoclonal antibody AC144. are widely used as specific markers to identify and isolate pDCs in research and diagnostics. These antibodies are valuable in studying pDC biology, including their involvement in autoimmune diseases (e.g., lupus), viral infections, and cancers. In pathology, CD303 immunohistochemistry aids in diagnosing blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare malignancy derived from pDCs. Therapeutic applications are under exploration, including anti-CD303-targeted therapies for autoimmune disorders or cancers. However, its ligand specificity and signaling mechanisms remain partially understood, prompting ongoing research to elucidate its broader immunological roles.

       
关键字: CD303抗体;CD303;CD303 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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