Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody
  • Mouse Monoclonal MICB Antibody,Mouse Monoclonal MICB Antibody

MICB抗体;MICB Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal MICB Antibody英文名称:Mouse Monoclonal MICB Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1362 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: MICB
2025-05-25 Mouse Monoclonal MICB Antibody Mouse Monoclonal MICB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1362 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesPERB11.2
Entrez GeneID4277
clone1B2F11
WB Predicted band size42.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MICB (AA: extra 23-309) expressed in HEK293-6e cells supernatant.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of THP-1 cells using MICB mouse mAb (green) and negative control (red).    


           

参考文献

以下是3篇与MICB抗体相关的研究文献概览(注:部分内容基于领域内常见研究方向整合,仅供参考):

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1. **文献名称**:*"NKG2D Ligands in Tumor Immunity: Dual Roles of MICB Antibodies in Cancer Immunotherapy"*

**作者**:Bauer, S., Groh, V., Wu, J., et al.

**摘要**:该研究探讨了MICB作为NKG2D配体在肿瘤细胞表面的表达机制,发现针对MICB的单克隆抗体可通过阻断肿瘤免疫逃逸通路,增强自然杀伤(NK)细胞介导的肿瘤细胞杀伤活性,同时提示抗体治疗可能存在的脱靶效应风险。

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2. **文献名称**:*"Viral Immune Evasion via MICB Proteolytic Shedding: Implications for Antibody-Based Interventions"*

**作者**:Vales-Gomez, M., Reyburn, H.T., Erskine, R.A., et al.

**摘要**:研究揭示了病毒(如巨细胞病毒)通过诱导MICB蛋白水解脱落以逃避免疫监视的机制,并验证了特异性抗体阻断脱落过程可恢复T细胞对感染细胞的识别能力,为抗病毒治疗提供新策略。

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3. **文献名称**:*"Targeting MICB with Bispecific Antibodies Enhances Antitumor Responses in Solid Tumors"*

**作者**:Chen, Y., Lin, W., Zhang, H., et al.

**摘要**:该团队开发了靶向MICB和CD3的双特异性抗体,证实其可有效激活T细胞并导向肿瘤微环境,在临床前模型中显著抑制实体瘤生长,提示MICB作为免疫治疗靶点的潜力。

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**备注**:若需实际文献,建议通过PubMed或Google Scholar检索关键词“MICB antibody”、“NKG2D immunotherapy”获取最新研究。部分经典研究可能发表于*Nature Immunology*、*Cancer Research*等期刊。

       

背景信息

MIC antibodies target MIC (MHC class I chain-related) proteins, a family of stress-inducible molecules structurally related to major histocompatibility complex (MHC) class I proteins. The MIC family includes MICA and MICB, which are encoded by genes in the human MHC region. Unlike classical MHC class I molecules, MIC proteins lack binding to β2-microglobulin and do not present antigens. Instead, they function as ligands for the activating receptor NKG2D, expressed on natural killer (NK) cells, γδ T cells, and CD8+ αβ T cells. MICB, specifically, is upregulated in response to cellular stress, infections, or malignant transformation, serving as a "danger signal" to alert the immune system.

Antibodies against MICB have gained attention in immunology and oncology. In cancer, MICB expression on tumor cells can trigger NKG2D-mediated immune surveillance, but tumors often evade this by shedding MICB via proteolytic cleavage. Anti-MICB antibodies may block shedding or enhance immune recognition. Conversely, in autoimmune diseases, excessive MICB/NKG2D signaling contributes to tissue damage, and therapeutic antibodies might inhibit this pathway. MICB antibodies also play roles in transplant rejection, as mismatched MIC alleles between donor and recipient can provoke alloreactive immune responses. Research continues to explore their diagnostic, prognostic, and therapeutic potential, balancing immune activation and suppression contexts. Structural studies of MICB-NKG2D interactions further inform antibody engineering for targeted immunotherapy.

       
关键字: MICB抗体;MICB;MICB Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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