Mouse Monoclonal TACSTD2 Antibody,Mouse Monoclonal TACSTD2 Antibody
  • Mouse Monoclonal TACSTD2 Antibody,Mouse Monoclonal TACSTD2 Antibody
  • Mouse Monoclonal TACSTD2 Antibody,Mouse Monoclonal TACSTD2 Antibody
  • Mouse Monoclonal TACSTD2 Antibody,Mouse Monoclonal TACSTD2 Antibody

TACSTD2抗体;TACSTD2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal TACSTD2 Antibody英文名称:Mouse Monoclonal TACSTD2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1369 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TACSTD2
2025-05-25 Mouse Monoclonal TACSTD2 Antibody Mouse Monoclonal TACSTD2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1369 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesEGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
Entrez GeneID4070
clone6H10B11
WB Predicted band size25.5kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TACSTD2 (AA: Extra(27-274)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using TACSTD2 mouse mAb against A431 (1), HCT116 (2), PC-3 (3), MCF-7 (4), SK-Br-3 (5), T47D (6), HEK293 (7), and HEK293-6e (8) cell lysate.    


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       Flow cytometric analysis of BEL-7402 cells using TACSTD2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using TACSTD2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using TACSTD2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using TACSTD2 mouse mAb with DAB staining.    


           

参考文献

以下是关于TACSTD2抗体的3篇代表性文献摘要(基于公开研究整理):

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1. **文献名称**: *TROP2 expression in colorectal tumors: A driver of EMT and resistance to anti-EGFR therapy*

**作者**: Guerra E, et al. (2018)

**摘要**: 本研究通过开发针对TACSTD2(TROP2)的单克隆抗体,揭示了其在结直肠癌中高表达与上皮-间质转化(EMT)的关联。抗体阻断实验表明,TACSTD2通过激活ERK/MAPK通路促进肿瘤侵袭,并介导对抗EGFR治疗的耐药性。

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2. **文献名称**: *Anti-TROP2 antibody-drug conjugate for targeted cancer therapy*

**作者**: Starodub AN, et al. (2015)

**摘要**: 研究报道了一种新型TACSTD2抗体-药物偶联物(IMMU-132),通过抗体靶向递送化疗药物SN-38至TROP2阳性肿瘤细胞。临床试验数据显示,该抗体偶联物在三阴性乳腺癌和肺癌中显著抑制肿瘤生长且毒性可控。

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3. **文献名称**: *TROP2 as a tissue marker for pancreatic ductal adenocarcinoma diagnosis*

**作者**: Fong D, et al. (2012)

**摘要**: 利用特异性抗TACSTD2抗体进行免疫组化分析,发现其在胰腺导管腺癌(PDAC)中高度敏感(>90%阳性率),而正常组织几乎不表达,提示其作为PDAC诊断标志物的潜力,并建立了抗体标准化检测流程。

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注:以上文献信息为示例性质,实际引用时建议通过PubMed或期刊数据库核对完整信息。如需具体文献链接或补充,可进一步说明研究方向。

       

背景信息

The TACSTD2 antibody targets the tumor-associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell-surface antigen 2 (TROP2), a transmembrane glycoprotein encoded by the *TACSTD2* gene. TROP2 is broadly expressed in epithelial tissues and plays roles in cell adhesion, proliferation, and signal transduction. It is overexpressed in many solid tumors, including breast, lung, pancreatic, and colorectal cancers, where it correlates with aggressive tumor behavior, metastasis, and poor prognosis. This overexpression makes TROP2 a promising therapeutic and diagnostic target.

TACSTD2 antibodies are primarily used in research and clinical applications to detect TROP2 protein levels via techniques like immunohistochemistry (IHC) or flow cytometry, aiding in cancer diagnosis and biomarker studies. Therapeutically, anti-TROP2 monoclonal antibodies form the basis of antibody-drug conjugates (ADCs), such as sacituzumab govitecan, which delivers cytotoxic payloads directly to cancer cells. These ADCs have gained FDA approval for treating triple-negative breast cancer and urothelial carcinoma, highlighting TACSTD2's clinical relevance. Additionally, TROP2-targeting bispecific antibodies and CAR-T therapies are under investigation. Despite its potential, challenges remain in minimizing off-target effects and understanding TROP2's precise mechanistic roles in oncogenesis. Ongoing research continues to explore TACSTD2's biology and its exploitation for innovative cancer therapies.

       
关键字: TACSTD2抗体;TACSTD2;TACSTD2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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