TIMD4抗体;TIMD4 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Jurkat cells using TIMD4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of Hela cells using TIMD4 mouse mAb (green) and negative control (red).    

  
  

TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4) is a transmembrane protein belonging to the TIM family, which plays roles in immune regulation. It contains an immunoglobulin variable (IgV) domain and a mucin-like domain, structurally conserved across TIM proteins. TIMD4 is expressed on immune cells, including macrophages, dendritic cells, and activated T cells, and interacts with phosphatidylserine (PS) exposed on apoptotic cells, facilitating their clearance. This function links TIMD4 to the maintenance of immune tolerance and prevention of autoimmunity.

TIMD4 antibodies are tools used to study its expression, localization, and function in immune responses. They are employed in techniques like flow cytometry, immunohistochemistry, and Western blotting. Research suggests TIMD4 may influence T-cell activation, cytokine production, and autoimmune diseases such as lupus or rheumatoid arthritis. Recent studies also explore its role in tumor microenvironments and cancer immunotherapy. Commercial TIMD4 antibodies are typically monoclonal, raised in mice or rabbits, and validated for specificity via knockout controls. Understanding TIMD4's mechanisms could advance therapies targeting immune dysregulation or apoptotic clearance pathways.