The scavenger receptor class B type 1 (SCARB1), also known as SR-BI, is a cell surface glycoprotein that plays a critical role in cholesterol metabolism, particularly in mediating the uptake of high-density lipoprotein (HDL)-derived cholesterol and cholesteryl esters into cells. SCARB1 antibodies are essential tools for studying its expression, localization, and function in various tissues, including the liver, adrenal glands, and endothelial cells. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to investigate SCARB1's involvement in lipid transport, atherosclerosis, and metabolic disorders.
Research using SCARB1 antibodies has highlighted its dual role in health and disease. While it promotes reverse cholesterol transport (protecting against cardiovascular disease), its overexpression in certain cancers may facilitate tumor progression by enhancing lipid uptake. Antibodies targeting specific epitopes or post-translational modifications of SCARB1 help elucidate its interaction partners, regulatory mechanisms, and therapeutic potential. Species-specific SCARB1 antibodies (e.g., human, mouse, rat) enable cross-species comparative studies. Validation of antibody specificity through knockout controls remains crucial, given structural similarities within the scavenger receptor family. Ongoing studies continue to explore SCARB1's link to viral entry pathways and inflammatory responses, expanding its biomedical relevance.