Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody
  • Mouse Monoclonal GOLGA2 Antibody,Mouse Monoclonal GOLGA2 Antibody

GOLGA2抗体;GOLGA2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:Mouse Monoclonal GOLGA2 Antibody英文名称:Mouse Monoclonal GOLGA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1407 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: GOLGA2
2025-05-25 Mouse Monoclonal GOLGA2 Antibody Mouse Monoclonal GOLGA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1407 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesGM130
Entrez GeneID2801
clone2D3D12
WB Predicted band size113kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GOLGA2 (AA: 1-205) expressed in HEK293-6e cells supernatant.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using GOLGA2 mouse mAb against HepG2 (1), Hela (2), K562 (3), and HEK293 (4) cell lysate.    


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       Immunofluorescence analysis of Hela cells using GOLGA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using GOLGA2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using GOLGA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using GOLGA2 mouse mAb with DAB staining.    


           

参考文献

以下为3篇与GOLGA2抗体相关的研究文献示例:

1. **文献名称**:Golgin-84 is required for Golgi structure formation during mitosis

**作者**:Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M

**摘要**:该研究利用GOLGA2(GM130)抗体探究高尔基体基质蛋白(包括GM130和golgin-84)在细胞分裂过程中维持高尔基体碎片化结构的作用,发现这些蛋白对高尔基体重新组装至关重要。

2. **文献名称**:Expression of Golgi protein GOLGA2 in colorectal cancer progression and its clinical significance

**作者**:Lin Y, Xu J, Lu H, et al.

**摘要**:通过免疫组化分析GOLGA2在结直肠癌组织中的表达,发现其高表达与肿瘤转移和不良预后相关,提示GOLGA2可能作为癌症生物标志物。

3. **文献名称**:Herpes simplex virus 1 cytoplasmic envelopment requires functional Golgi recruitment by its membrane protein US10

**作者**:Metrick CM, Koenigsberg AL, Heldwein EE

**摘要**:研究利用GOLGA2抗体标记高尔基体,发现疱疹病毒US10蛋白通过干扰高尔基体结构促进病毒包膜形成,揭示病毒劫持宿主细胞器的机制。

注:以上文献为示例,实际引用时建议通过PubMed等数据库核对最新研究。GOLGA2抗体常用于研究高尔基体结构、癌症及病毒感染机制。

       

背景信息

GOLGA2 antibodies are primarily associated with research on the Golgi apparatus and autoimmune disorders. GOLGA2. also known as Golgin A2 or GM130. is a peripheral membrane protein located on the Golgi stack. It plays a critical role in maintaining Golgi structure, vesicle trafficking, and glycosylation processes. Antibodies targeting GOLGA2 are widely used as markers in immunofluorescence and immunoblotting to visualize the Golgi complex in cellular studies.

In clinical contexts, GOLGA2 autoantibodies have been identified in certain autoimmune conditions. Notably, they are detected in a subset of patients with paraneoplastic syndromes, particularly those with cancer-associated retinopathy (CAR) or melanoma-associated retinopathy (MAR). These autoantibodies may arise due to molecular mimicry between tumor antigens and retinal proteins, triggering immune cross-reactivity. Additionally, GOLGA2 antibodies have been reported in rare cases of autoimmune hepatitis and connective tissue disorders, though their pathogenicity remains unclear.

Research also links GOLGA2 dysregulation to cancer progression. Overexpression of GOLGA2 is observed in malignancies like hepatocellular carcinoma and colorectal cancer, potentially influencing cell proliferation and metastasis. However, most studies focus on its role as an autoantigen or structural protein rather than a therapeutic target. Continued investigation aims to clarify its diagnostic utility and mechanistic contributions to disease pathways.

       
关键字: GOLGA2抗体;GOLGA2;GOLGA2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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