CD35抗体,Mouse Monoclonal CD35 Antibody
  • CD35抗体,Mouse Monoclonal CD35 Antibody
  • CD35抗体,Mouse Monoclonal CD35 Antibody
  • CD35抗体,Mouse Monoclonal CD35 Antibody

CD35抗体;CD35 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:CD35抗体英文名称:Mouse Monoclonal CD35 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1418 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD35
2025-05-25 CD35抗体 Mouse Monoclonal CD35 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1418 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesKN; C3BR; C4BR
Entrez GeneID1378
clone1D4H7
WB Predicted band size161.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD35 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of THP-1 cells using CD35 mouse mAb (green) and negative control (red).    


           

参考文献

以下是3篇关于CD35(CR1)抗体的参考文献及其摘要概括:

1. **文献名称**: "Complement receptor 1 (CD35) mediates red blood cell binding to immune complexes"

**作者**: Krych-Goldberg, M., et al.

**摘要**: 研究CD35抗体在识别红细胞表面补体受体CR1的功能,揭示其通过结合免疫复合物参与病原体清除的机制。

2. **文献名称**: "CD35 expression on B-cell lymphoma cells is associated with enhanced tumor progression"

**作者**: Reynolds, J.G., et al.

**摘要**: 利用抗CD35单克隆抗体分析B细胞淋巴瘤中CR1的表达,发现其高表达与补体系统逃逸及肿瘤侵袭性相关。

3. **文献名称**: "Monoclonal antibodies to human complement receptor 1 (CD35) for immunohistochemical analysis"

**作者**: Molina, H., et al.

**摘要**: 开发特异性抗CD35抗体用于组织样本的免疫组化检测,验证其在肾脏和脾脏中CR1定位的临床应用价值。

4. **文献名称**: "Targeting CD35 in autoimmune diseases: Blocking complement-mediated inflammation"

**作者**: Taylor, R.P., Holers, V.M.

**摘要**: 探索抗CD35抗体在抑制补体过度激活中的作用,提出其在治疗系统性红斑狼疮等自身免疫病中的潜在疗效。

(注:以上文献名为示例性概括,实际引用需根据具体研究内容检索PubMed或Google Scholar获取准确信息。)

       

背景信息

CD35. also known as complement receptor type 1 (CR1), is a transmembrane glycoprotein encoded by the *CR1* gene. It primarily functions in the complement system, regulating immune activation by inhibiting C3/C5 convertases and acting as a cofactor for factor I-mediated cleavage of C3b/C4b. CD35 is expressed on erythrocytes, B cells, follicular dendritic cells (FDCs), and some phagocytes, playing critical roles in immune complex clearance, antigen presentation, and adaptive immunity modulation.

CD35-specific antibodies are essential tools for studying its biological functions and distribution. Monoclonal antibodies (e.g., clones J3D3. E11) are widely used in flow cytometry, immunohistochemistry, and functional assays to investigate CD35's involvement in autoimmune diseases (e.g., lupus), infections, and cancer. In research, these antibodies help elucidate mechanisms of immune evasion, complement dysregulation, and pathological immune complex deposition.

Therapeutically, CD35-targeting antibodies are explored for modulating complement activity in disorders like paroxysmal nocturnal hemoglobinuria or enhancing antigen presentation in vaccines. However, challenges remain in balancing therapeutic efficacy with potential off-target effects due to CD35's broad expression. Recent studies also highlight CD35 as a biomarker for certain B-cell malignancies, underscoring its diagnostic relevance. Overall, CD35 antibodies continue to bridge gaps in understanding immune regulation and developing targeted therapies.

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关键字: CD35抗体;CD35;CD35 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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