XRCC1抗体,Mouse Monoclonal XRCC1 Antibody
  • XRCC1抗体,Mouse Monoclonal XRCC1 Antibody
  • XRCC1抗体,Mouse Monoclonal XRCC1 Antibody
  • XRCC1抗体,Mouse Monoclonal XRCC1 Antibody

XRCC1抗体;XRCC1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:XRCC1抗体英文名称:Mouse Monoclonal XRCC1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1425 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: XRCC1
2025-05-25 XRCC1抗体 Mouse Monoclonal XRCC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1425 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesFLJ32198, MGC10902, p35, UPIIIb
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human UPK3B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P00029(UPK3B Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P00029(UPK3B Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P00029(UPK3B Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇与XRCC1抗体相关的文献摘要信息,供参考:

1. **"XRCC1 interacts with the human DNA repair enzyme PARP and stimulates its activity after DNA damage"**

*Author: Kubota Y. et al.*

摘要:研究通过免疫共沉淀和Western blot分析,利用XRCC1抗体揭示了XRCC1与PARP蛋白的相互作用,并证明XRCC1在DNA损伤后增强PARP酶活性,促进单链断裂修复。

2. **"Expression of XRCC1 and clinicopathological parameters in breast cancer"**

*Author: Abdel-Fatah T.M. et al.*

摘要:通过免疫组化(使用XRCC1特异性抗体)分析乳腺癌组织中XRCC1蛋白表达水平,发现低表达与患者预后不良及化疗耐药性相关,提示其作为潜在生物标志物的价值。

3. **"XRCC1 deficiency increases DNA damage and alters genomic stability in human cells"**

*Author: Thompson L.H. et al.*

摘要:利用XRCC1抗体进行细胞定位和功能研究,发现XRCC1缺失导致DNA损伤修复能力下降,染色体畸变率升高,证实其在维持基因组稳定性中的关键作用。

注:以上文献为示例性概括,实际引用时建议通过PubMed或Web of Science检索最新研究,并核对原文细节。

       

背景信息

The XRCC1 (X-ray repair cross-complementing protein 1) antibody is a crucial tool for studying DNA repair mechanisms, particularly base excision repair (BER) and single-strand break repair (SSBR). XRCC1 is a scaffold protein that lacks enzymatic activity but coordinates key repair components, including DNA ligase IIIα, PARP1. and polynucleotide kinase, to maintain genomic stability. Antibodies targeting XRCC1 are widely used in research to detect its expression, localization, and interaction partners in various biological contexts. They are employed in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate XRCC1’s role in cellular responses to DNA damage induced by radiation, oxidative stress, or chemotherapeutic agents.

XRCC1 antibodies are typically raised in rabbits or mice using immunogenic peptides or recombinant protein fragments, with monoclonal and polyclonal variants available. These antibodies help elucidate XRCC1’s involvement in diseases linked to defective DNA repair, including cancer, neurodegenerative disorders, and aging-related pathologies. For example, reduced XRCC1 expression or polymorphisms in its gene have been associated with increased cancer susceptibility. Researchers also use these antibodies to explore XRCC1’s potential as a biomarker for predicting therapeutic responses or prognosis in patients undergoing DNA-damaging treatments. Validation via knockout cell lines or siRNA knockdown is critical to ensure antibody specificity due to XRCC1’s complex protein interactions.

       
关键字: XRCC1抗体;XRCC1;XRCC1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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