TRIB2抗体;TRIB2 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using TRIB2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of Jurkat cells using TRIB2 mouse mAb (green) and negative control (red).    

  
  

TRIB2 (Tribbles homolog 2) is a pseudokinase protein belonging to the Tribbles family, which regulates diverse cellular processes, including differentiation, apoptosis, and cancer progression. TRIB2 antibodies are essential tools for detecting and studying this protein's expression, localization, and functional roles. Structurally, TRIB2 lacks catalytic kinase activity but interacts with key signaling molecules via its pseudokinase domain and binding motifs, such as the MEK1-binding region. It is implicated in modulating pathways like the MAPK/ERK cascade and ubiquitin-mediated degradation of targets (e.g., C/EBPα in leukemia).

Research using TRIB2 antibodies has highlighted its oncogenic potential in various cancers, including acute myeloid leukemia, lung cancer, and liver cancer, where its overexpression correlates with poor prognosis and therapy resistance. Conversely, TRIB2 also exhibits context-dependent roles, such as promoting apoptosis in certain solid tumors. Antibodies against TRIB2 enable investigations into its dual roles in cancer progression and suppression, as well as its involvement in autoimmune diseases (e.g., rheumatoid arthritis) and metabolic disorders.

These antibodies are critical for Western blotting, immunohistochemistry, and co-immunoprecipitation studies, aiding in the exploration of TRIB2's molecular mechanisms and its potential as a therapeutic target or biomarker.