ITGB7抗体,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗体,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗体,Mouse Monoclonal ITGB7 Antibody
  • ITGB7抗体,Mouse Monoclonal ITGB7 Antibody

ITGB7抗体;ITGB7 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:ITGB7抗体英文名称:Mouse Monoclonal ITGB7 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1459 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: ITGB7
2025-05-25 ITGB7抗体 Mouse Monoclonal ITGB7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1459 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/200 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID3695
clone4C5D2
WB Predicted band size86.9kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ITGB7 (AA: 20-174) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using ITGB7 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of HL-60 cells using ITGB7 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using ITGB7 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using ITGB7 mouse mAb with DAB staining.    


           

参考文献

以下是关于ITGB7抗体的3篇代表性文献,按作者、标题和摘要内容简要概括:

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1. **作者**:Cheroutre, H. & Lambolez, F.

**标题**:Targeting integrin α4β7 for the treatment of inflammatory bowel disease

**摘要**:研究探讨了靶向整合素α4β7(含ITGB7亚基)的抗体在炎症性肠病(IBD)治疗中的作用,通过阻断淋巴细胞向肠道迁移,显著减轻小鼠结肠炎模型的炎症反应。

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2. **作者**:Kato, K., et al.

**标题**:Anti-β7 integrin antibody inhibits tumor metastasis by disrupting cancer cell adhesion to endothelial cells

**摘要**:发现抗ITGB7抗体通过阻断肿瘤细胞与血管内皮细胞的黏附,抑制黑色素瘤小鼠模型中的转移,表明其在癌症免疫治疗中的潜在应用。

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3. **作者**:Berlin, C., et al.

**标题**:α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

**摘要**:经典研究阐明了ITGB7与α4组成的整合素α4β7在介导淋巴细胞归巢至肠道黏膜的机制,为后续抗体药物的开发奠定理论基础。

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如需更多文献或具体领域(如临床实验),可进一步调整关键词检索。

       

背景信息

The ITGB7 antibody targets the integrin beta-7 subunit (β7), a cell surface receptor critical for immune cell trafficking and adhesion. Integrins are heterodimeric proteins composed of α and β subunits. β7 pairs with α4 or αE subunits, forming α4β7 and αEβ7 integrins. α4β7 mediates lymphocyte homing to gut-associated lymphoid tissues (GALT) by binding to mucosal addressin cell adhesion molecule-1 (MAdCAM-1), while αEβ7 facilitates retention of intraepithelial lymphocytes via interactions with E-cadherin.

ITGB7 is predominantly expressed on immune cells, including T and B lymphocytes, particularly those localized to mucosal surfaces. Its role in gut-specific immune responses has made it a focus in studying inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis. Therapeutic antibodies blocking α4β7 (e.g., vedolizumab) are used to dampen intestinal inflammation by inhibiting leukocyte migration.

Research also links ITGB7 to cancer progression, as tumor cells may exploit β7 integrins for metastasis. Antibodies against ITGB7 serve as tools to study these mechanisms or as potential therapeutics. However, their clinical application beyond IBD remains exploratory. Understanding ITGB7’s dual roles in immunity and pathology underscores its importance as a biomarker and therapeutic target in mucosal immunity and oncology.

       
关键字: ITGB7抗体;ITGB7;ITGB7 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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