SOCS3抗体,Mouse Monoclonal SOCS3 Antibody
  • SOCS3抗体,Mouse Monoclonal SOCS3 Antibody
  • SOCS3抗体,Mouse Monoclonal SOCS3 Antibody
  • SOCS3抗体,Mouse Monoclonal SOCS3 Antibody

SOCS3抗体;SOCS3 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:SOCS3抗体英文名称:Mouse Monoclonal SOCS3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1465 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SOCS3
2025-05-25 SOCS3抗体 Mouse Monoclonal SOCS3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1465 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Entrez GeneID9021
clone3A10A12
WB Predicted band size24.8KDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SOCS3 (AA: full(1-225)) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using SOCS3 mouse mAb against Hela cell lysate.    


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       Immunofluorescence analysis of Hela cells using SOCS3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SOCS3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using SOCS3 mouse mAb with DAB staining.    


           

参考文献

以下是关于SOCS3抗体的3篇代表性文献示例(文献信息为示例性质,请通过学术平台核实原文):

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1. **文献名称**:*Suppressor of cytokine signaling-3 is a key regulator of the pro-inflammatory response in human macrophages*

**作者**:Yasukawa H. et al.

**摘要**:本研究利用SOCS3特异性抗体,揭示了SOCS3通过抑制JAK-STAT信号通路负调控巨噬细胞中IL-6等促炎因子的产生,为炎症性疾病治疗提供靶点。

2. **文献名称**:*SOCS3 deficiency in myeloid cells promotes obesity-induced inflammation and insulin resistance*

**作者**:Lavine S.D. et al.

**摘要**:通过SOCS3抗体检测小鼠模型中的蛋白表达,发现髓系细胞中SOCS3缺失会加剧肥胖相关炎症和胰岛素抵抗,证实其在代谢调控中的关键作用。

3. **文献名称**:*SOCS3 overexpression drives STAT3 signaling suppression and enhances chemosensitivity in leukemia cells*

**作者**:He B. et al.

**摘要**:利用SOCS3抗体进行Western blot分析,证明过表达SOCS3可通过抑制STAT3磷酸化增强白血病细胞对化疗药物的敏感性,提示其作为癌症治疗标志物的潜力。

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**建议**:可通过PubMed或Google Scholar检索关键词“SOCS3 antibody”、“SOCS3 function”获取最新文献,并注意选择高引用研究或权威期刊论文以保障可靠性。

       

背景信息

SOCS3 (Suppressor of Cytokine Signaling 3) antibodies are essential tools for studying the regulation of cytokine signaling pathways in cellular and molecular research. SOCS3 is a member of the SOCS family, which negatively regulates the JAK-STAT signaling cascade by binding to cytokine receptors or JAK kinases, targeting them for proteasomal degradation. It plays a critical role in modulating immune responses, inflammation, and cancer progression. SOCS3 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect SOCS3 protein expression levels, localization, and interactions in various biological samples.

These antibodies are typically raised against specific epitopes of human or mouse SOCS3. with monoclonal and polyclonal variants available. Monoclonal antibodies offer high specificity, while polyclonal antibodies may provide broader detection across species. Researchers utilize SOCS3 antibodies to explore its involvement in diseases such as cancer (e.g., tumor suppression or oncogenic roles), autoimmune disorders, and metabolic conditions like obesity and insulin resistance. Challenges in working with SOCS3 antibodies include low endogenous protein expression in certain tissues, potential cross-reactivity with other SOCS family members (e.g., SOCS1 or SOCS2), and variability due to post-translational modifications. Proper validation using knockout controls or siRNA-based knockdown is critical to ensure specificity. Commercial SOCS3 antibodies often cite applications in both normal and pathological contexts, emphasizing their utility in uncovering mechanisms of cytokine signaling dysregulation.

       
关键字: SOCS3抗体;SOCS3;SOCS3 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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