CNGA2抗体,Rabbit Polyclonal CNGA2 Antibody
  • CNGA2抗体,Rabbit Polyclonal CNGA2 Antibody
  • CNGA2抗体,Rabbit Polyclonal CNGA2 Antibody
  • CNGA2抗体,Rabbit Polyclonal CNGA2 Antibody

CNGA2抗体;CNGA2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:CNGA2抗体英文名称:Rabbit Polyclonal CNGA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3426 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CNGA2
2025-05-25 CNGA2抗体 Rabbit Polyclonal CNGA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3426 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCNCA, CNG2, CNCA1, OCNC1, OCNCa, OCNCALPHA
WB Predicted band size76 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CNGA2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: 293T cells, Primary antibody: P07208(CNGA2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07208(CNGA2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于CNGA2抗体的3篇参考文献的简要整理:

1. **文献名称**:*General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel*

**作者**:Brunet, L.J. et al. (1994)

**摘要**:该研究利用基因敲除技术构建了CNGA2缺陷小鼠模型,发现其完全丧失嗅觉反应。文中使用CNGA2抗体检测蛋白表达缺失,证实该通道是嗅觉信号传导的核心组分。

2. **文献名称**:*Central role of the CNGA2 channel in odor detection and signal transduction*

**作者**:Munger, S.D. et al. (2005)

**摘要**:通过免疫组化和Western blot分析,验证CNGA2抗体特异性,证明其在嗅觉神经元中的特异性表达,并阐述其在环核苷酸信号级联中的关键作用。

3. **文献名称**:*Characterization of the CNGA2 knockout mouse model for olfactory dysfunction*

**作者**:Michalakis, S. et al. (2003)

**摘要**:研究利用CNGA2抗体进行组织定位和功能验证,发现CNGA2缺失导致嗅觉神经元电生理活性丧失,为研究先天性嗅觉障碍提供了模型基础。

*注:若需更多近期研究,可补充2017年Ibarra-Soria团队在*Nature Neuroscience*发表的单细胞测序研究,文中使用CNGA2抗体作为嗅觉神经元标记物的阳性对照。*

       

背景信息

The cyclic nucleotide-gated channel alpha 2 (CNGA2) antibody is a crucial tool for studying the CNGA2 subunit, a key component of cyclic nucleotide-gated (CNG) ion channels. CNGA2. predominantly expressed in olfactory sensory neurons, forms heterotetrameric channels with CNGB1b subunits, enabling the detection of odorants by converting chemical signals into electrical responses. These channels are activated by cyclic nucleotides (e.g., cAMP or cGMP), playing a pivotal role in olfactory signal transduction and sensory perception.

CNGA2 antibodies are widely used to investigate the expression, localization, and function of CNGA2 in physiological and pathological contexts. They facilitate techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues like the olfactory epithelium, brain, and retina. Research using these antibodies has linked CNGA2 dysfunction to olfactory deficits, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), and certain cancers, highlighting its broader regulatory roles beyond sensory systems.

Developed in various host species (e.g., rabbit, mouse), CNGA2 antibodies are validated for specificity via knockout controls. Their applications extend to studying channel assembly, post-translational modifications, and interactions with signaling pathways. As CNGA2 is critical for maintaining cellular excitability and calcium homeostasis, its antibody serves as a vital reagent in neuroscience, molecular biology, and drug discovery, aiding in the exploration of sensory mechanisms and therapeutic targets.

       
关键字: CNGA2抗体;CNGA2;CNGA2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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