ASIC3抗体;ASIC3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P11546(ASIC3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The acid-sensing ion channel 3 (ASIC3), encoded by the ACCN3 gene, is a proton-gated cation channel belonging to the DEG/ENaC superfamily. It is predominantly expressed in peripheral sensory neurons, particularly in nociceptors, and plays a critical role in detecting extracellular acidification during tissue injury, inflammation, or ischemia. ASIC3 activation contributes to pain signaling, mechanosensation, and proprioception. Its sensitivity to pH changes (activation threshold ~pH 6.7) makes it a key mediator in chronic pain conditions like arthritis, migraine, and visceral hypersensitivity.

ASIC3 antibodies are essential tools for studying the channel's expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to map ASIC3 distribution in tissues or assess its regulation under disease states. Some antibodies target specific epitopes to distinguish between isoforms or post-translationally modified forms. Research using ASIC3 antibodies has revealed its involvement in neuroinflammatory responses, acidosis-related neuronal damage, and interactions with signaling molecules (e.g., serotonin, lactate). Recent studies also explore ASIC3's role in non-neuronal tissues, including bone and cancer cells. Validating antibody specificity remains crucial due to structural similarities among ASIC subunits. Reliable ASIC3 antibodies aid in developing therapeutic strategies targeting acid-mediated pathologies.