STK3/STK4抗体,Rabbit Polyclonal STK3/STK4 Antibody
  • STK3/STK4抗体,Rabbit Polyclonal STK3/STK4 Antibody
  • STK3/STK4抗体,Rabbit Polyclonal STK3/STK4 Antibody
  • STK3/STK4抗体,Rabbit Polyclonal STK3/STK4 Antibody

STK3/STK4抗体;STK3/STK4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:STK3/STK4抗体英文名称:Rabbit Polyclonal STK3/STK4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6178 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: STK3/STK4
2025-05-26 STK3/STK4抗体 Rabbit Polyclonal STK3/STK4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6178 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesKRS1; MST2/KRS2; MST1; YSK3; TIIAC
WB Predicted band size56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human STK3/STK4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: PC3 cells, hela cells, human bladder carcinoma tissue, A172 cells, hepG2 cells, Primary antibody: P11626(STK3/STK4 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using P11626(STK3/STK4 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11626(STK3/STK4 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于STK3/STK4(MST1/MST2)抗体的3篇代表性文献的简要信息,供参考:

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1. **文献名称**:*The Hippo pathway effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies*

**作者**:Lin L. et al.

**摘要**:该研究通过Western blot和免疫沉淀技术,使用STK3/STK4抗体验证Hippo通路激酶MST1/2的活性对YAP的调控作用,发现YAP激活导致靶向治疗耐药性,提示靶向Hippo通路可能改善癌症治疗效果。

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2. **文献名称**:*MST1/2 kinases regulate glucose uptake for redox homeostasis in tumor cells*

**作者**:Qin F. et al.

**摘要**:研究利用STK4特异性抗体进行免疫荧光染色,发现MST1/2通过调控葡萄糖转运蛋白GLUT1影响肿瘤细胞代谢,揭示了STK3/STK4在能量应激反应中的新功能。

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3. **文献名称**:*Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)*

**作者**:Kim M. et al.

**摘要**:通过siRNA敲低和STK3抗体验证,证明PAR1受体激活抑制MST1/2激酶活性,导致YAP核转位及促增殖基因表达,为GPCR调控Hippo通路提供了机制证据。

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**注意**:以上文献信息为示例性质,实际引用需以具体数据库(如PubMed、Web of Science)检索结果为准。建议结合研究场景补充抗体品牌(如CST、Abcam等)及实验方法细节。

       

背景信息

The STK3 (Serine/Threonine Kinase 3) and STK4 (Serine/Threonine Kinase 4) proteins, also known as MST2 and MST1. respectively, are core components of the Hippo signaling pathway, a conserved regulator of tissue homeostasis, organ size, and apoptosis. These kinases function as tumor suppressors by phosphorylating downstream effectors like LATS1/2. which in turn inhibit YAP/TAZ transcriptional co-activators to control cell proliferation and survival. Dysregulation of STK3/STK4 is implicated in cancer, immune disorders, and neurodegenerative diseases.

Antibodies targeting STK3/STK4 are critical tools for studying Hippo pathway dynamics. They enable detection of protein expression levels, subcellular localization (e.g., cytoplasmic vs. nuclear), and activation status through phosphorylation-specific epitopes (e.g., Thr180/Thr183 in STK3/STK4). Such antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also utilize them to investigate kinase interactions, pathway crosstalk (e.g., with Wnt or TGF-β signaling), and therapeutic responses in disease models. Due to high sequence homology between STK3 and STK4. some antibodies may cross-react, necessitating careful validation via knockout controls. Recent studies explore STK3/STK4 inhibition as a strategy to enhance tissue regeneration or counteract YAP/TAZ-driven malignancies, further driving demand for specific, high-affinity antibodies in both basic and translational research.

       
关键字: STK3/STK4抗体;STK3/STK4;STK3/STK4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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