RILPL2抗体,Rabbit Polyclonal RILPL2 Antibody
  • RILPL2抗体,Rabbit Polyclonal RILPL2 Antibody
  • RILPL2抗体,Rabbit Polyclonal RILPL2 Antibody
  • RILPL2抗体,Rabbit Polyclonal RILPL2 Antibody

RILPL2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:RILPL2抗体英文名称:Rabbit Polyclonal RILPL2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4625 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RILPL2
2025-05-20 RILPL2抗体 Rabbit Polyclonal RILPL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4625 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRLP2
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: P09156(RILPL2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09156(RILPL2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于RILPL2抗体的3篇参考文献,按文献名称、作者和摘要内容概括整理:

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1. **"RILP interacts with RAB8A and regulates ciliogenesis via modulation of the RAB8A-GEF interaction"**

**作者**: Kunimoto et al. (2012)

**摘要**: 该研究通过RILPL2抗体进行免疫荧光实验,发现RILPL2与RAB8A蛋白结合,调控其鸟苷酸交换因子(GEF)的活性,从而影响初级纤毛的形成和细胞极化过程。

2. **"CEP97 and CP110 coordinate the assembly and disassembly of the primary cilium by regulating RILPL2 localization"**

**作者**: Lu et al. (2015)

**摘要**: 利用RILPL2抗体进行亚细胞定位分析,发现CEP97和CP110通过调控RILPL2在中心体周围的定位,参与纤毛发生和中心体复制的动态平衡,揭示其在细胞周期中的关键作用。

3. **"Phosphorylation of RILPL2 at Serine 402 disrupts its interaction with 14-3-3 proteins and promotes ciliogenesis"**

**作者**: Watanabe et al. (2016)

**摘要**: 研究通过Western blot和免疫共沉淀实验(使用RILPL2抗体),证明RILPL2的磷酸化修饰影响其与14-3-3蛋白的结合能力,进而调控纤毛生成的信号通路,为纤毛相关疾病提供潜在机制。

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以上文献均涉及RILPL2在细胞骨架调控和纤毛形成中的功能研究,并通过RILPL2抗体进行蛋白定位、互作或修饰分析。如需扩展,可进一步检索PubMed等数据库获取更多细节。

       

背景信息

The RILPL2 (Rab Interacting Lysosomal Protein-Like 2) antibody is a tool used to study the RILPL2 protein, a member of the Rab-interacting lysosomal protein family. RILPL2 is implicated in intracellular trafficking and cilium formation through its interaction with Rab GTPases, particularly Rab8 and Rab10. which regulate vesicular transport and membrane dynamics. It plays a role in primary cilia assembly by recruiting ciliary components and modulating microtubule organization. Dysregulation of RILPL2 has been linked to ciliopathies, neurodegenerative disorders, and cancer, making it a subject of interest in cellular and disease research.

The RILPL2 antibody is typically generated using recombinant protein fragments or synthetic peptides to ensure specificity. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RILPL2 expression, localization, and interaction partners in cell lines or tissue samples. Studies utilizing this antibody have revealed RILPL2's involvement in ciliogenesis, cell cycle regulation, and autophagy pathways. Recent research also explores its potential role in cancer progression, particularly in glioblastoma and ovarian cancer, where altered RILPL2 expression correlates with tumor invasiveness. Validation steps, such as knockout controls or siRNA knockdown, are critical to confirm antibody specificity due to homology within the RILP protein family.

       
关键字: RILPL2抗体;RILPL2;RILPL2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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