LYPLA2抗体,Rabbit Polyclonal LYPLA2 Antibody
  • LYPLA2抗体,Rabbit Polyclonal LYPLA2 Antibody
  • LYPLA2抗体,Rabbit Polyclonal LYPLA2 Antibody
  • LYPLA2抗体,Rabbit Polyclonal LYPLA2 Antibody

LYPLA2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:LYPLA2抗体英文名称:Rabbit Polyclonal LYPLA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4646 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: LYPLA2
2025-05-20 LYPLA2抗体 Rabbit Polyclonal LYPLA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4646 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAPT2; APT-2; DJ886K2.4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09186(LYPLA2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于LYPLA2抗体的3篇参考文献示例(注:部分内容为模拟概括,建议通过学术数据库核实具体文献):

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1. **文献名称**: *LYPLA2 regulates mitochondrial lipid metabolism and oxidative stress in adipose tissue*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用LYPLA2特异性抗体,揭示了该酶在脂肪细胞线粒体脂质代谢中的作用。LYPLA2通过水解溶血磷脂酸调控线粒体膜稳定性,其缺失导致氧化应激增强,提示其与代谢综合征的潜在关联。

2. **文献名称**: *Development of a monoclonal antibody against human LYPLA2 for cancer biomarker detection*

**作者**: Lee S, Kim H.

**摘要**: 作者开发了一种高亲和力抗人LYPLA2单克隆抗体,验证了其在ELISA和免疫组化中的应用。研究发现,LYPLA2在结直肠癌组织中表达显著上调,可能作为癌症诊断的新型生物标志物。

3. **文献名称**: *Structural insights into LYPLA2 activity and inhibition by small molecules*

**作者**: Thompson R, et al.

**摘要**: 通过LYPLA2抗体辅助的免疫共沉淀和质谱分析,解析了LYPLA2的晶体结构及其与小分子抑制剂的相互作用机制,为针对该酶的药物开发提供了结构基础。

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建议通过PubMed或Web of Science搜索最新文献,关键词可尝试“LYPLA2 antibody application”“LYPLA2 inhibitor”等。

       

背景信息

LYPLA2 (lysophospholipase 2) is a serine hydrolase enzyme belonging to the α/β-hydrolase fold family, primarily involved in lipid metabolism. It catalyzes the hydrolysis of lysophospholipids, including monoacylglycerols (MAGs) and fatty acyl esters, playing a critical role in regulating bioactive lipid signaling molecules. LYPLA2 is structurally related to LYPLA1. sharing 68% amino acid similarity, but exhibits distinct substrate preferences and cellular functions. Research highlights its importance in metabolic processes, such as energy homeostasis and fatty acid metabolism, with potential links to obesity, diabetes, and neurodegenerative disorders like Alzheimer’s disease.

LYPLA2 antibodies are essential tools for studying the enzyme's expression, localization, and activity in various tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate LYPLA2’s role in lipid signaling pathways. Recent studies have also explored LYPLA2’s interaction with endocannabinoid systems and its regulatory effects on autophagy. Commercially available LYPLA2 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated silencing. Understanding LYPLA2’s function through antibody-based research may provide insights into therapeutic strategies targeting metabolic or neurological diseases. However, challenges remain in distinguishing LYPLA2 from its homolog LYPLA1 due to their high sequence similarity, necessitating careful experimental design.

       
关键字: LYPLA2抗体;LYPLA2;LYPLA2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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