XPO6抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09269(XPO6 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09269(XPO6 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The XPO6 antibody is a research tool targeting Exportin 6 (XPO6/Exp6), a nuclear export receptor belonging to the karyopherin-β family. XPO6 primarily mediates the transport of specific cargo proteins, including actin and certain transcription factors, from the nucleus to the cytoplasm. This process is critical for maintaining cellular homeostasis, cytoskeletal dynamics, and gene expression regulation. Dysregulation of XPO6 has been implicated in diseases such as cancer, where aberrant nuclear-cytoplasmic trafficking may promote tumor progression.

The XPO6 antibody is widely used in molecular biology to study protein localization, expression levels, and interaction partners via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its development stems from the need to explore XPO6's role in cellular processes, including cell motility, differentiation, and stress responses. Recent studies also highlight its potential as a biomarker or therapeutic target, particularly in cancers with disrupted nuclear transport pathways. Validation of XPO6 antibodies typically involves knockout cell lines or siRNA knockdown to confirm specificity, ensuring reliable detection of the ~125 kDa protein. Ongoing research continues to unravel its tissue-specific functions and disease associations.