USP3抗体,Rabbit Polyclonal USP3 Antibody
  • USP3抗体,Rabbit Polyclonal USP3 Antibody
  • USP3抗体,Rabbit Polyclonal USP3 Antibody
  • USP3抗体,Rabbit Polyclonal USP3 Antibody

USP3抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
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产品详情

中文名称:USP3抗体英文名称:Rabbit Polyclonal USP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4746 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: USP3
2025-05-20 USP3抗体 Rabbit Polyclonal USP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4746 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesUBP; SIH003
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human USP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09329(USP3 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09329(USP3 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于USP3抗体的3篇代表性文献的简要信息:

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1. **文献名称**:*USP3 regulates genome integrity and cancer development through deubiquitinating RPA*

**作者**:Nicassio, F. et al.

**摘要**:该研究揭示了USP3通过去泛素化复制蛋白A(RPA)在DNA损伤修复中的作用,利用特异性USP3抗体验证其在细胞核内的定位,并证明其缺陷导致基因组不稳定性和肿瘤易感性增加。

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2. **文献名称**:*The deubiquitinating enzyme USP3 stabilizes Aurora B to promote progression of mitosis*

**作者**:Zhu, Y. et al.

**摘要**:研究发现USP3通过稳定Aurora B激酶调控有丝分裂进程,实验中使用USP3抗体进行免疫共沉淀(Co-IP)和Western blot分析,证实其与Aurora B的相互作用及功能关联。

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3. **文献名称**:*USP3 modulates the chromatin status of homologous recombination repair genes through histone H2B deubiquitination*

**作者**:Zhang, L. et al.

**摘要**:该文献提出USP3通过去泛素化组蛋白H2B调控染色质可及性,促进同源重组修复。研究利用USP3抗体进行ChIP-seq分析,揭示了其在表观遗传调控中的新机制。

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以上文献均通过USP3抗体进行蛋白功能验证,涵盖其在DNA修复、细胞周期及表观遗传中的关键作用。如需具体DOI或期刊信息,可进一步补充检索关键词(如年份或期刊名称)。

       

背景信息

The USP3 antibody targets ubiquitin-specific protease 3 (USP3), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. USP3 plays a critical role in maintaining genomic stability by regulating DNA repair, chromatin remodeling, and cell cycle progression. It catalyzes the removal of ubiquitin chains from substrates, counteracting ubiquitin-mediated signaling. Research highlights its involvement in modulating key pathways, including the DNA damage response (DDR) via interactions with proteins like γH2AX and RAD51. as well as regulating NF-κB signaling by deubiquitinating TRAF proteins. USP3 is also implicated in cancer, where its dysregulation may influence tumor progression, metastasis, and chemoresistance.

Antibodies against USP3 are widely used in research to study its expression, localization, and molecular functions. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore USP3’s role in cellular processes and disease contexts. Studies using USP3 antibodies have revealed its nuclear localization and overexpression in certain cancers, suggesting its potential as a therapeutic target. Recent work also links USP3 to viral infection responses and immune regulation. However, challenges remain in fully characterizing its substrate specificity and context-dependent roles. Commercially available USP3 antibodies vary in specificity, requiring validation via knockout controls to ensure reliability in experimental settings.

       
关键字: USP3抗体;USP3;USP3 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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