The BHMT2 antibody is a research tool used to detect and study Betaine-Homocysteine S-Methyltransferase 2 (BHMT2), an enzyme involved in the methionine cycle and homocysteine metabolism. BHMT2 catalyzes the conversion of homocysteine to methionine using S-methylmethionine as a methyl donor, complementing the function of BHMT1. which uses betaine. This enzyme plays a role in maintaining cellular methylation potential and redox balance, particularly in tissues like the liver and kidneys. BHMT2 is structurally related to BHMT1 but exhibits distinct substrate preferences and regulatory mechanisms. Its expression and activity are linked to folate-independent pathways, making it relevant in conditions influenced by homocysteine levels, such as cardiovascular diseases, liver disorders, and neurological impairments. The BHMT2 antibody enables researchers to investigate protein expression patterns, subcellular localization, and tissue distribution via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have explored BHMT2's role in metabolic syndromes, genetic polymorphisms affecting enzyme efficiency, and its interplay with dietary factors. However, commercial availability and validation data may vary, requiring careful optimization in experimental settings. Understanding BHMT2's function through antibody-based assays contributes to insights into sulfur amino acid metabolism and therapeutic targeting of related pathologies.