ZMYND10 (zinc finger MYND domain-containing protein 10) is a cytoplasmic protein encoded by the *ZMYND10* gene, primarily expressed in ciliated tissues. It plays a critical role in regulating the assembly and function of motile cilia by stabilizing proteins in the axonemal dynein complex. Mutations in *ZMYND10* are linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, leading to chronic respiratory infections, infertility, and situs inversus.
Antibodies targeting ZMYND10 are essential tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ZMYND10 in tissue samples or cultured cells. These antibodies help identify protein expression deficits in PCD patients and validate disease models. Commercial ZMYND10 antibodies are typically raised in rabbits or mice, with validation in knockdown/knockout controls to ensure specificity. Recent studies also explore ZMYND10’s potential roles beyond ciliopathies, including cancer, where its dysregulation may influence tumor progression. However, research remains focused on elucidating its cilia-related mechanisms, emphasizing the antibody’s diagnostic and research value in understanding ciliary biology and related disorders.