The C15orf40 antibody is a research tool designed to detect the human protein encoded by the *C15orf40* gene (Chromosome 15 Open Reading Frame 40). This gene, located on chromosome 15q22.31. is evolutionarily conserved and ubiquitously expressed across tissues, with higher levels observed in the testis, bone marrow, and lymphoid organs. While its precise biological function remains under investigation, emerging studies suggest C15orf40 may play roles in DNA repair, cell cycle regulation, and tumorigenesis. It has been implicated in homologous recombination repair (HRR) pathways, interacting with proteins like BRCA1 and RAD51. potentially influencing cancer cell responses to DNA-damaging therapies.
C15orf40 antibodies, typically developed as polyclonal or monoclonal reagents, are used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression, localization, and dynamics. Dysregulation of C15orf40 has been observed in cancers, including breast, colorectal, and prostate malignancies, linking its expression to disease progression and therapeutic resistance. Commercial antibodies are often validated for specificity using knockout cell lines or siRNA knockdowns.
Research on C15orf40 is expanding due to its potential as a biomarker or therapeutic target, particularly in cancers with defective DNA repair mechanisms. However, functional studies remain limited, necessitating further exploration of its molecular mechanisms and clinical relevance.