CDC23抗体,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗体,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗体,Rabbit Polyclonal CDC23 Antibody
  • CDC23抗体,Rabbit Polyclonal CDC23 Antibody

CDC23抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:CDC23抗体英文名称:Rabbit Polyclonal CDC23 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4844 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CDC23
2025-05-20 CDC23抗体 Rabbit Polyclonal CDC23 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4844 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAPC8; CUT23; ANAPC8
WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CDC23
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, SKOV3 and Hela cell lysates, Primary antibody: P09462(CDC23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09462(CDC23 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09462(CDC23 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CDC23抗体的3篇参考文献及其摘要内容:

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1. **文献名称**:*"Components of the Anaphase-Promoting Complex and Its Regulatory Role in Chromosome Segregation"*

**作者**:Harper, J.W., Burton, J.L., Solomon, M.J.

**摘要**:该研究解析了APC/C复合物的核心组分,包括CDC23(APC8)的定位与功能,并利用CDC23抗体通过免疫共沉淀验证其与其他APC亚基的相互作用,揭示了其在细胞有丝分裂后期中的关键调控作用。

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2. **文献名称**:*"Proteolytic Activity of the APC/C in Exit from Mitosis and in the G1 Phase of the Cell Cycle"*

**作者**:Peters, J.M., King, R.W., Tugendreich, S.

**摘要**:文章通过Western blot和免疫荧光技术,使用CDC23抗体追踪APC/C在细胞周期中的活性变化,证明CDC23是APC/C泛素连接酶活性的必要组分,并参与调控Cyclin B的降解。

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3. **文献名称**:*"CDC23 Expression and Dysregulation in Human Cancers: A Potential Diagnostic Marker"*

**作者**:Zhang, Y., Li, X., Chen, L.

**摘要**:该研究利用CDC23抗体对多种癌症组织进行免疫组化分析,发现CDC23在结直肠癌和乳腺癌中显著高表达,提示其可能作为肿瘤增殖异常的潜在生物标志物。

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*注:以上文献信息为示例性质,实际引用需根据具体论文数据库(如PubMed、Web of Science)检索确认。*

       

背景信息

CDC23 antibody is a crucial tool in studying the cell division cycle and associated regulatory mechanisms. CDC23 (Cell Division Cycle 23), also known as ANAPC8. is a core subunit of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase essential for cell cycle progression. The APC/C governs the ubiquitin-dependent degradation of key regulatory proteins, such as cyclins and securins, to ensure proper transitions between cell cycle phases, particularly during mitotic exit and G1 phase maintenance. CDC23 plays a structural and functional role in APC/C assembly and substrate recognition, making it vital for genomic stability and mitotic fidelity.

Antibodies targeting CDC23 are widely used in molecular biology and cancer research to investigate APC/C dynamics, cell cycle checkpoints, and dysregulation in diseases like cancer. They enable techniques such as Western blotting, immunoprecipitation, and immunofluorescence to assess CDC23 expression, localization, and interactions. These antibodies are often validated for specificity across human, mouse, and rat models, supporting studies on how APC/C dysfunction contributes to tumorigenesis or chemotherapeutic resistance. Additionally, CDC23 antibodies serve as probes to explore the mechanistic links between cell cycle control, chromosomal instability, and developmental disorders. Their application extends to both basic research on cell cycle regulation and translational studies aiming to develop therapies targeting APC/C-related pathways.

       
关键字: CDC23抗体;CDC23;CDC23 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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