The CEP57 antibody is a research tool designed to detect CEP57 (Centrosomal Protein 57), a key component of the centrosome involved in cell division and microtubule organization. CEP57. a 57 kDa protein, plays critical roles in mitotic spindle assembly, microtubule anchoring to centrosomes, and maintaining genomic stability by regulating proper chromosome segregation. It also interacts with proteins like PCNA and RAD51. suggesting roles in DNA repair. Dysregulation of CEP57 is linked to chromosomal instability, aneuploidy, and cancer progression. Notably, germline mutations in the CEP57 gene cause Mosaic Variegated Aneuploidy (MVA) syndrome, a rare disorder characterized by developmental defects and cancer predisposition.
CEP57 antibodies, often produced in rabbits or mice using recombinant protein immunogens, enable the study of CEP57's expression, localization, and function via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are vital for exploring centrosome biology, mitotic errors, and disease mechanisms. In cancer research, they help assess CEP57's role as a potential biomarker or therapeutic target. Validation of specificity through knockout controls or siRNA knockdown is essential for reliable experimental outcomes. Overall, CEP57 antibodies are indispensable tools in cell biology and translational research, bridging molecular insights with clinical applications.