CTRC抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09508(CTRC Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

CTRC (Chymotrypsin C) is a serine protease encoded by the CTRC gene, primarily synthesized in the pancreas. It plays a critical role in digestive enzyme regulation by activating and inactivating zymogens (inactive enzyme precursors) such as trypsinogen, chymotrypsinogen, and procarboxypeptidase. CTRC ensures proper digestion by preventing premature enzyme activation within pancreatic cells, which could lead to autodigestion and tissue damage. Mutations in the CTRC gene are associated with chronic pancreatitis, as impaired CTRC function disrupts trypsin regulation, promoting inflammation and fibrosis.

CTRC antibodies are essential tools for studying this enzyme’s expression, localization, and function in both physiological and pathological contexts. In research, they help elucidate CTRC’s role in pancreatic diseases, including its interaction with other proteases and inhibitors. Clinically, these antibodies aid in diagnosing pancreatitis-linked genetic variants or quantifying CTRC levels in biological samples. Additionally, they contribute to therapeutic development, such as targeting protease pathways in pancreatitis or pancreatic cancer. Recent studies also explore CTRC’s broader roles beyond digestion, including immune modulation and tissue remodeling. However, challenges remain in standardizing antibody specificity and sensitivity for diverse applications. Advances in monoclonal antibody technology continue to enhance CTRC-related diagnostics and research precision.