CLASP2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09518(CLASP2 Antibody) at dilution 1/110. (Original magnification: ×200)    

  
  

CLASP2 (cytoplasmic linker-associated protein 2) is a microtubule-associated protein critical for regulating cytoskeletal dynamics, cell polarity, and intracellular trafficking. It belongs to the CLASP family, which includes CLASP1 and CLASP2. both sharing conserved N- and C-terminal domains that mediate interactions with microtubules, actin filaments, and other regulatory proteins like CLIP-170. CLASP2 is particularly involved in stabilizing microtubules at specific subcellular regions, such as the cell cortex or growing microtubule plus-ends, and plays a role in mitosis, cell migration, and organelle transport. Its dysfunction has been linked to neurodevelopmental disorders, cancer metastasis, and compromised neuronal connectivity.

Antibodies targeting CLASP2 are essential tools for studying its localization, expression, and function. They are widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize CLASP2 distribution during cell division, neuronal development, or epithelial polarization. Many CLASP2 antibodies are raised against specific epitopes, such as the N-terminal coiled-coil region or C-terminal domains, ensuring specificity. Validated antibodies help elucidate CLASP2's role in diseases; for example, reduced CLASP2 levels correlate with impaired axonal guidance, while its overexpression in tumors may promote invasive behavior. Researchers often verify antibody specificity using knockout cell lines or siRNA knockdowns to minimize cross-reactivity with CLASP1. Commercial CLASP2 antibodies are available from multiple suppliers, with applications spanning basic cell biology to translational cancer research.