DACT2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09588(DACT2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

DACT2 (Dapper Homolog 2), a member of the Dapper (DACT) gene family, is a cytoplasmic protein involved in regulating Wnt signaling pathways, particularly by modulating β-catenin-dependent and -independent pathways. It acts as a scaffold protein, interacting with key components like Dishevelled (Dvl) to inhibit or enhance Wnt signaling, depending on cellular context. DACT2 is implicated in embryonic development, tissue homeostasis, and cancer progression. Research highlights its tumor-suppressive role in multiple cancers, including colorectal, gastric, and hepatocellular carcinomas, where its expression is frequently downregulated due to promoter hypermethylation. This epigenetic silencing correlates with advanced tumor stages, metastasis, and poor prognosis.

DACT2 antibodies are critical tools for investigating its expression patterns, functional mechanisms, and clinical relevance. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence to detect protein levels in tissues or cell lines. Commercially available polyclonal or monoclonal antibodies target specific epitopes, aiding in studies exploring DACT2’s interaction networks and post-translational modifications. Recent studies also utilize these antibodies to validate DACT2’s role in suppressing epithelial-mesenchymal transition (EMT) and metastasis via Wnt/β-catenin pathway inhibition. As DACT2 gains attention as a potential biomarker or therapeutic target, its antibodies remain essential for both basic research and translational applications in oncology.