The NHP2 antibody is a crucial tool in studying the NHP2 protein, a component of the H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. NHP2. along with proteins like dyskerin, GAR1. and NOP10. plays a vital role in ribosomal RNA (rRNA) processing, telomerase RNA stabilization, and post-transcriptional modifications such as pseudouridylation. This complex is essential for ribosome biogenesis and telomere maintenance, linking NHP2 dysfunction to genetic disorders like dyskeratosis congenita (DKC), a condition characterized by bone marrow failure, skin abnormalities, and increased cancer risk.
Antibodies targeting NHP2 are widely used in molecular and cellular biology to investigate its expression, localization, and interactions within the H/ACA complex. They enable techniques like Western blotting, immunoprecipitation, and immunofluorescence, helping researchers dissect NHP2's role in ribosome assembly, telomere biology, and disease mechanisms. Studies using these antibodies have revealed how mutations in NHP2 disrupt rRNA processing and telomerase activity, contributing to DKC pathogenesis and cancer progression. Additionally, NHP2 antibodies are valuable in exploring connections between ribosomopathies, aging-related disorders, and telomere-associated diseases. Their application extends to diagnostic research, aiding in the identification of molecular biomarkers for early disease detection or therapeutic targeting.